Farah Wahida Suhaimi, Nurul Husna Mohamad Khari, Zurina Hassan, Christian P Müller
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Exploring the cognitive effects of kratom: A review.
Despite the strict kratom regulation in some regions, the demand for kratom products is still increasing worldwide. Kratom products are commonly consumed for their pain-relieving effect or as a self-treatment for opioid use disorder. Kratom is also taken as a recreational drug among youth and adults. Since substance abuse can cause cognitive impairment, many studies investigated the effects of kratom on cognition. The interaction of some kratom alkaloids with various receptors such as opioid, serotonergic, and adrenergic receptors further sparks the interest to investigate the effects of kratom on cognitive function. Hence, this review aims to provide an overview of the effects of kratom on cognitive behaviours and their underlying changes in neurobiological mechanisms. In conclusion, kratom, particularly its main alkaloid, mitragynine may adversely affect cognitive performances that may be attributed to the disruption in synaptic plasticity, brain activity as well as various proteins involved in synaptic transmission. The impact of kratom on cognitive functions could also shed light on its safety profile, which is essential for the therapeutic development of kratom, including its potential use in opioid substitution therapy.
期刊介绍：
Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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