组学时代的高复用成像：理解健康和疾病中的组织结构

IF 36.1 1区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Nature Methods Pub Date : 2024-12-06 DOI:10.1038/s41592-024-02538-6

Bernd Bodenmiller

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引用次数: 0

摘要

空间蛋白质组学正在迅速发展，通过研究多细胞结构和细胞间通讯如何影响健康和疾病中的组织功能，改变了生理和生物医学研究。通过对大量人体组织的分析，空间蛋白质组学将揭示人体组织的复杂性，揭示可作为药物靶点和诊断的多细胞模块，为精准医学和组织病理学的革命铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Highly multiplexed imaging in the omics era: understanding tissue structures in health and disease

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Highly multiplexed imaging in the omics era: understanding tissue structures in health and disease

Spatial proteomics is advancing rapidly, transforming physiological and biomedical research by enabling the study of how multicellular structures and intercellular communication shape tissue function in health and disease. Through the analysis of large human tissue collections, spatial proteomics will reveal the complexities of human tissues and uncover multicellular modules that can serve as drug targets and diagnostics, paving the way for precision medicine and revolutionizing histopathology.

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来源期刊

Nature Methods 生物-生化研究方法

CiteScore

58.70

自引率

1.70%

发文量

326

审稿时长

1 months

期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.