单细胞分辨率下基于ms的蛋白质组学对组织生物学的新认识

IF 36.1 1区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Nature Methods Pub Date : 2024-12-06 DOI:10.1038/s41592-024-02541-x

Thierry M. Nordmann, Andreas Mund, Matthias Mann

{"title":"单细胞分辨率下基于ms的蛋白质组学对组织生物学的新认识","authors":"Thierry M. Nordmann, Andreas Mund, Matthias Mann","doi":"10.1038/s41592-024-02541-x","DOIUrl":null,"url":null,"abstract":"Spatial mass spectrometry (MS)-proteomics is a rapidly evolving technology, particularly in the form of Deep Visual Proteomics (DVP), which allows the study of single cells directly in their native environment. We believe that this approach will reshape our understanding of tissue biology and redefine fundamental concepts in cell biology, tissue physiology and ultimately human health and disease.","PeriodicalId":18981,"journal":{"name":"Nature Methods","volume":"21 12","pages":"2220-2222"},"PeriodicalIF":36.1000,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A new understanding of tissue biology from MS-based proteomics at single-cell resolution\",\"authors\":\"Thierry M. Nordmann, Andreas Mund, Matthias Mann\",\"doi\":\"10.1038/s41592-024-02541-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Spatial mass spectrometry (MS)-proteomics is a rapidly evolving technology, particularly in the form of Deep Visual Proteomics (DVP), which allows the study of single cells directly in their native environment. We believe that this approach will reshape our understanding of tissue biology and redefine fundamental concepts in cell biology, tissue physiology and ultimately human health and disease.\",\"PeriodicalId\":18981,\"journal\":{\"name\":\"Nature Methods\",\"volume\":\"21 12\",\"pages\":\"2220-2222\"},\"PeriodicalIF\":36.1000,\"publicationDate\":\"2024-12-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Methods\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41592-024-02541-x\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Methods","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41592-024-02541-x","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

摘要

空间质谱(MS)-蛋白质组学是一项快速发展的技术，特别是以深度视觉蛋白质组学（DVP）的形式，它允许直接在其天然环境中研究单细胞。我们相信这种方法将重塑我们对组织生物学的理解，并重新定义细胞生物学、组织生理学以及最终人类健康和疾病的基本概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A new understanding of tissue biology from MS-based proteomics at single-cell resolution

查看原文本刊更多论文

A new understanding of tissue biology from MS-based proteomics at single-cell resolution

Spatial mass spectrometry (MS)-proteomics is a rapidly evolving technology, particularly in the form of Deep Visual Proteomics (DVP), which allows the study of single cells directly in their native environment. We believe that this approach will reshape our understanding of tissue biology and redefine fundamental concepts in cell biology, tissue physiology and ultimately human health and disease.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Methods 生物-生化研究方法

CiteScore

58.70

自引率

1.70%

发文量

326

审稿时长

1 months

期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.