{"title":"类风湿关节炎间质性肺疾病患者幽门螺杆菌血清阳性率。","authors":"Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Akira Okamoto, Misuzu Fujimori, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama, Toshihiro Matsui, Naoshi Fukui, Kiyoshi Migita, Shigeto Tohma","doi":"10.1177/11772719241297171","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by <i>Helicobacter pylori</i> infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of <i>H. pylori</i> infection in RA patients with ILD has not been sufficiently investigated.</p><p><strong>Objective: </strong>In this study, we analyzed anti-<i>H. pylori</i> antibodies in RA patients with ILD.</p><p><strong>Design: </strong>Case-control observational study.</p><p><strong>Methods: </strong>Anti-<i>H. pylori</i> antibodies were analyzed in the sera of RA patients using a commercially available enzyme-linked immunosorbent assay kit.</p><p><strong>Results: </strong>The positivity of anti-<i>H. pylori</i> antibodies in RA with ILD (<i>n</i> = 30 [18.0%], <i>P</i> = .0227), usual interstitial pneumonia (<i>n</i> = 10 [14.3%], <i>P</i> = .0212), and airway disease (<i>n</i> = 30 [18.0%], <i>P</i> = .0227) was significantly lower than that of RA without chronic lung disease (<i>n</i> = 78 [27.5%]). The positivity of anti-<i>H. pylori</i> antibodies was also lower in RA with chronic lung disease (<i>n</i> = 68 [18.2%], <i>P</i> = .0059). Multiple logistic regression analyses showed that the presence of anti-<i>H. pylori</i> antibodies was independently and protectively associated with chronic lung disease in RA.</p><p><strong>Conclusion: </strong>The seroprevalence of <i>H. pylori</i> was lower in RA with ILD. <i>H. pylori</i> infection prevented ILD in patients with RA by protecting them from gastroesophageal reflux disease.</p>","PeriodicalId":47060,"journal":{"name":"Biomarker Insights","volume":"19 ","pages":"11772719241297171"},"PeriodicalIF":3.4000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618895/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Helicobacter pylori</i> Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease.\",\"authors\":\"Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Akira Okamoto, Misuzu Fujimori, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama, Toshihiro Matsui, Naoshi Fukui, Kiyoshi Migita, Shigeto Tohma\",\"doi\":\"10.1177/11772719241297171\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by <i>Helicobacter pylori</i> infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of <i>H. pylori</i> infection in RA patients with ILD has not been sufficiently investigated.</p><p><strong>Objective: </strong>In this study, we analyzed anti-<i>H. pylori</i> antibodies in RA patients with ILD.</p><p><strong>Design: </strong>Case-control observational study.</p><p><strong>Methods: </strong>Anti-<i>H. pylori</i> antibodies were analyzed in the sera of RA patients using a commercially available enzyme-linked immunosorbent assay kit.</p><p><strong>Results: </strong>The positivity of anti-<i>H. pylori</i> antibodies in RA with ILD (<i>n</i> = 30 [18.0%], <i>P</i> = .0227), usual interstitial pneumonia (<i>n</i> = 10 [14.3%], <i>P</i> = .0212), and airway disease (<i>n</i> = 30 [18.0%], <i>P</i> = .0227) was significantly lower than that of RA without chronic lung disease (<i>n</i> = 78 [27.5%]). The positivity of anti-<i>H. pylori</i> antibodies was also lower in RA with chronic lung disease (<i>n</i> = 68 [18.2%], <i>P</i> = .0059). Multiple logistic regression analyses showed that the presence of anti-<i>H. pylori</i> antibodies was independently and protectively associated with chronic lung disease in RA.</p><p><strong>Conclusion: </strong>The seroprevalence of <i>H. pylori</i> was lower in RA with ILD. <i>H. pylori</i> infection prevented ILD in patients with RA by protecting them from gastroesophageal reflux disease.</p>\",\"PeriodicalId\":47060,\"journal\":{\"name\":\"Biomarker Insights\",\"volume\":\"19 \",\"pages\":\"11772719241297171\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2024-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618895/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomarker Insights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/11772719241297171\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarker Insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11772719241297171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
背景：类风湿关节炎（RA）并发间质性肺疾病（ILD）。胃食管反流病可通过幽门螺杆菌感染预防，它是特发性肺纤维化的易感因素。然而，幽门螺杆菌感染在RA合并ILD患者中的患病率尚未得到充分的调查。目的：分析抗h。类风湿性关节炎合并ILD患者的幽门螺杆菌抗体。设计：病例对照观察性研究。方法:Anti-H。使用市售的酶联免疫吸附测定试剂盒分析RA患者血清中的幽门螺杆菌抗体。结果：抗h。合并ILD的RA （n = 30 [18.0%], P = 0.0227）、常见性间质性肺炎（n = 10 [14.3%], P = 0.0212）、气道疾病（n = 30 [18.0%], P = 0.0227）患者幽门螺杆菌抗体水平显著低于无慢性肺部疾病的RA （n = 78[27.5%]）。反氢原子的正电荷。类风湿性关节炎合并慢性肺病患者幽门螺杆菌抗体水平也较低（n = 68 [18.2%], P = 0.0059）。多元logistic回归分析表明，抗h。幽门螺杆菌抗体与类风湿关节炎患者的慢性肺部疾病独立且具有保护作用。结论：类风湿性关节炎合并ILD患者幽门螺杆菌血清阳性率较低。幽门螺杆菌感染通过保护RA患者免受胃食管反流疾病的侵袭来预防ILD。
Helicobacter pylori Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease.
Background: Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by Helicobacter pylori infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of H. pylori infection in RA patients with ILD has not been sufficiently investigated.
Objective: In this study, we analyzed anti-H. pylori antibodies in RA patients with ILD.
Design: Case-control observational study.
Methods: Anti-H. pylori antibodies were analyzed in the sera of RA patients using a commercially available enzyme-linked immunosorbent assay kit.
Results: The positivity of anti-H. pylori antibodies in RA with ILD (n = 30 [18.0%], P = .0227), usual interstitial pneumonia (n = 10 [14.3%], P = .0212), and airway disease (n = 30 [18.0%], P = .0227) was significantly lower than that of RA without chronic lung disease (n = 78 [27.5%]). The positivity of anti-H. pylori antibodies was also lower in RA with chronic lung disease (n = 68 [18.2%], P = .0059). Multiple logistic regression analyses showed that the presence of anti-H. pylori antibodies was independently and protectively associated with chronic lung disease in RA.
Conclusion: The seroprevalence of H. pylori was lower in RA with ILD. H. pylori infection prevented ILD in patients with RA by protecting them from gastroesophageal reflux disease.
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