麻疯树二萜具有多药耐药逆转活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI:10.1016/j.fitote.2024.106331

Yi-Lin He, Lan-Jun Zhang, Guo-Li Li, Hong-Ying Yang, Lei Zhang, Zheng Gong, Kun Gao

{"title":"麻疯树二萜具有多药耐药逆转活性。","authors":"Yi-Lin He, Lan-Jun Zhang, Guo-Li Li, Hong-Ying Yang, Lei Zhang, Zheng Gong, Kun Gao","doi":"10.1016/j.fitote.2024.106331","DOIUrl":null,"url":null,"abstract":"Nine jatrophane diterpenoids, including six previously undescribed compounds, were extracted and purified from whole plants of Jatropha curcas L. Their structures including absolute configurations were characterized by spectroscopic, quantum chemical Nuclear Magnetic Resonance Spectroscopy, Electronic Circular Dichroism calculation, and Single Crystal X-Ray Diffraction methods. These compounds were evaluated for their ability to reverse multidrug resistance. Among the above compounds, compound 6 showed significant potential as a multidrug resistance modulator, exhibiting higher chemo reversal effects and lower toxicity compared to the positive control verapamil. These findings suggest that compound 6 has promising anticancer properties.","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":" ","pages":"106331"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Jatrophane diterpenoids from Jatropha curcas with multidrug resistance reversal activity.\",\"authors\":\"Yi-Lin He, Lan-Jun Zhang, Guo-Li Li, Hong-Ying Yang, Lei Zhang, Zheng Gong, Kun Gao\",\"doi\":\"10.1016/j.fitote.2024.106331\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Nine jatrophane diterpenoids, including six previously undescribed compounds, were extracted and purified from whole plants of Jatropha curcas L. Their structures including absolute configurations were characterized by spectroscopic, quantum chemical Nuclear Magnetic Resonance Spectroscopy, Electronic Circular Dichroism calculation, and Single Crystal X-Ray Diffraction methods. These compounds were evaluated for their ability to reverse multidrug resistance. Among the above compounds, compound 6 showed significant potential as a multidrug resistance modulator, exhibiting higher chemo reversal effects and lower toxicity compared to the positive control verapamil. These findings suggest that compound 6 has promising anticancer properties.\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\" \",\"pages\":\"106331\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.fitote.2024.106331\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fitote.2024.106331","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/3 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

从麻疯树（Jatropha curcas L.）全株中提取纯化了9个麻疯树二萜类化合物，其中包括6个未见描述的化合物。采用光谱学、量子化学核磁共振、电子圆二色性计算和单晶x射线衍射等方法对它们的结构和绝对构型进行了表征。这些化合物因其逆转多药耐药的能力而被评估。在上述化合物中，化合物3作为多药耐药调节剂具有显著的潜力，与阳性对照维拉帕米相比，具有更高的化疗逆转作用和更低的毒性。这些发现表明化合物3具有很好的抗癌特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Jatrophane diterpenoids from Jatropha curcas with multidrug resistance reversal activity.

Nine jatrophane diterpenoids, including six previously undescribed compounds, were extracted and purified from whole plants of Jatropha curcas L. Their structures including absolute configurations were characterized by spectroscopic, quantum chemical Nuclear Magnetic Resonance Spectroscopy, Electronic Circular Dichroism calculation, and Single Crystal X-Ray Diffraction methods. These compounds were evaluated for their ability to reverse multidrug resistance. Among the above compounds, compound 6 showed significant potential as a multidrug resistance modulator, exhibiting higher chemo reversal effects and lower toxicity compared to the positive control verapamil. These findings suggest that compound 6 has promising anticancer properties.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.