体育锻炼训练对重度抑郁症工作记忆神经活动的影响。

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2024-12-03 DOI:10.1016/j.jad.2024.12.016

M.K. Schwefel , C. Kaufmann , G. Gutmann , R. Henze , T. Fydrich , M.A. Rapp , A. Ströhle , A. Heissel , S. Heinzel

{"title":"体育锻炼训练对重度抑郁症工作记忆神经活动的影响。","authors":"M.K. Schwefel , C. Kaufmann , G. Gutmann , R. Henze , T. Fydrich , M.A. Rapp , A. Ströhle , A. Heissel , S. Heinzel","doi":"10.1016/j.jad.2024.12.016","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Deficits in working memory (WM) are common in patients with Major Depression Disorder (MDD). Previous research mainly in healthy adults indicated that physical exercise training may improve cognitive functions by stimulating neuronal plasticity particularly in hippocampal structures. Thus, the goal of this functional Magnetic Resonance Imaging (fMRI) study was to examine alterations in neuronal activity during a WM task and to investigate changes in brain volume and functioning following a physical exercise training in patients with MDD with a specific focus on hippocampal structures.</div></div><div><h3>Methods</h3><div>86 (39 female) MDD outpatients (average age 37.3), diagnosed by clinical psychologists, were randomly assigned to one of three groups for a 12-week intervention: High intensity exercise training (HEX), low intensity exercise training (LEX) or waiting list control group (WL). An n-back task (with WM loads of 0, 1, 2, and 3) during fMRI was conducted before and after interventions/waiting period.</div></div><div><h3>Results</h3><div>Both exercise groups showed better performance and shorter reaction times at higher WM loads after 12-weeks of physical exercise training. Specifically in the HEX, we found an improvement in physical fitness and an increase in neural activation in the left hippocampus as compared to the WL following the exercise training. Training-related structural volume changes in gray matter or hippocampus were not detected.</div></div><div><h3>Conclusions</h3><div>Our results partly support the hypothesis that physical exercise training positively affects WM functions by improving neuronal plasticity in hippocampal regions. Exercise training seems to be a promising intervention to improve deficient WM performance in patients with MDD.</div></div><div><h3>Clinical trials registration name</h3><div>Neurobiological correlates and mechanisms of the augmentation of psychotherapy with endurance exercise in mild to moderate depression - SPeED, <span><span>http://apps.who.int/trialsearch/Trial2.aspx?TrialID=DRKS00008869</span><svg><path></path></svg></span>, DRKS00008869.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"372 ","pages":"Pages 269-278"},"PeriodicalIF":4.9000,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of physical exercise training on neural activity during working memory in major depressive disorder\",\"authors\":\"M.K. Schwefel , C. Kaufmann , G. Gutmann , R. Henze , T. Fydrich , M.A. Rapp , A. Ströhle , A. Heissel , S. Heinzel\",\"doi\":\"10.1016/j.jad.2024.12.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Deficits in working memory (WM) are common in patients with Major Depression Disorder (MDD). Previous research mainly in healthy adults indicated that physical exercise training may improve cognitive functions by stimulating neuronal plasticity particularly in hippocampal structures. Thus, the goal of this functional Magnetic Resonance Imaging (fMRI) study was to examine alterations in neuronal activity during a WM task and to investigate changes in brain volume and functioning following a physical exercise training in patients with MDD with a specific focus on hippocampal structures.</div></div><div><h3>Methods</h3><div>86 (39 female) MDD outpatients (average age 37.3), diagnosed by clinical psychologists, were randomly assigned to one of three groups for a 12-week intervention: High intensity exercise training (HEX), low intensity exercise training (LEX) or waiting list control group (WL). An n-back task (with WM loads of 0, 1, 2, and 3) during fMRI was conducted before and after interventions/waiting period.</div></div><div><h3>Results</h3><div>Both exercise groups showed better performance and shorter reaction times at higher WM loads after 12-weeks of physical exercise training. Specifically in the HEX, we found an improvement in physical fitness and an increase in neural activation in the left hippocampus as compared to the WL following the exercise training. Training-related structural volume changes in gray matter or hippocampus were not detected.</div></div><div><h3>Conclusions</h3><div>Our results partly support the hypothesis that physical exercise training positively affects WM functions by improving neuronal plasticity in hippocampal regions. Exercise training seems to be a promising intervention to improve deficient WM performance in patients with MDD.</div></div><div><h3>Clinical trials registration name</h3><div>Neurobiological correlates and mechanisms of the augmentation of psychotherapy with endurance exercise in mild to moderate depression - SPeED, <span><span>http://apps.who.int/trialsearch/Trial2.aspx?TrialID=DRKS00008869</span><svg><path></path></svg></span>, DRKS00008869.</div></div>\",\"PeriodicalId\":14963,\"journal\":{\"name\":\"Journal of affective disorders\",\"volume\":\"372 \",\"pages\":\"Pages 269-278\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-12-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of affective disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165032724019955\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032724019955","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：工作记忆缺陷（WM）在重度抑郁症（MDD）患者中很常见。以往主要针对健康成人的研究表明，体育锻炼可以通过刺激神经元的可塑性，特别是海马结构的可塑性来改善认知功能。因此，这项功能性磁共振成像（fMRI）研究的目的是研究在WM任务中神经元活动的变化，并研究重度抑郁症患者在进行体育锻炼训练后脑容量和功能的变化，并特别关注海马结构。方法：86例（39名女性）经临床心理学家诊断为MDD门诊患者（平均年龄37.3岁），随机分为三组进行为期12周的干预：高强度运动训练（HEX）、低强度运动训练（LEX）或等候名单对照组（WL）。在干预/等待期之前和之后，在fMRI期间进行n-back任务（WM负载为0、1、2和3）。结果：经过12周的体育锻炼训练，两组在高WM负荷下均表现出更好的表现和更短的反应时间。特别是在HEX中，我们发现与运动训练后的WL相比，身体健康有所改善，左侧海马体的神经激活也有所增加。训练相关的灰质或海马体结构体积变化未被检测到。结论：我们的研究结果在一定程度上支持了体育锻炼通过改善海马区域的神经元可塑性而积极影响WM功能的假设。运动训练似乎是一种有希望的干预措施，以改善缺乏WM患者的MDD表现。临床试验注册名称：轻度至中度抑郁症心理治疗与耐力运动增强的神经生物学相关性及机制- SPeED， http://apps.who.int/trialsearch/Trial2.aspx?TrialID=DRKS00008869, DRKS00008869。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Effect of physical exercise training on neural activity during working memory in major depressive disorder

Background

Deficits in working memory (WM) are common in patients with Major Depression Disorder (MDD). Previous research mainly in healthy adults indicated that physical exercise training may improve cognitive functions by stimulating neuronal plasticity particularly in hippocampal structures. Thus, the goal of this functional Magnetic Resonance Imaging (fMRI) study was to examine alterations in neuronal activity during a WM task and to investigate changes in brain volume and functioning following a physical exercise training in patients with MDD with a specific focus on hippocampal structures.

Methods

86 (39 female) MDD outpatients (average age 37.3), diagnosed by clinical psychologists, were randomly assigned to one of three groups for a 12-week intervention: High intensity exercise training (HEX), low intensity exercise training (LEX) or waiting list control group (WL). An n-back task (with WM loads of 0, 1, 2, and 3) during fMRI was conducted before and after interventions/waiting period.

Results

Both exercise groups showed better performance and shorter reaction times at higher WM loads after 12-weeks of physical exercise training. Specifically in the HEX, we found an improvement in physical fitness and an increase in neural activation in the left hippocampus as compared to the WL following the exercise training. Training-related structural volume changes in gray matter or hippocampus were not detected.

Conclusions

Our results partly support the hypothesis that physical exercise training positively affects WM functions by improving neuronal plasticity in hippocampal regions. Exercise training seems to be a promising intervention to improve deficient WM performance in patients with MDD.

Clinical trials registration name

Neurobiological correlates and mechanisms of the augmentation of psychotherapy with endurance exercise in mild to moderate depression - SPeED, http://apps.who.int/trialsearch/Trial2.aspx?TrialID=DRKS00008869, DRKS00008869.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.