Rab蛋白在破骨细胞细胞器生物发生和功能中的新作用。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-12-19 DOI:10.1042/BST20240519

Shiou-Ling Lu, Takeshi Noda

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引用次数: 0

摘要

兔GTPase蛋白因其在调节囊泡和细胞器动力学中的作用而被广泛研究。在哺乳动物细胞的约60种亚型中，有几种Rabs在破骨细胞的生物发生和功能中起着至关重要的作用。在这篇综述中，我们旨在提供最近描述的Rab11、Rab32、Rab44和Rab38以及Rab7、Rab3D和Rab27A在破骨细胞形成和功能中的最新进展。

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The emerging role of Rab proteins in osteoclast organelle biogenesis and function.

Rab GTPase proteins have been extensively studied for their roles in regulating vesicle and organelle dynamics. Among the ∼60 subtypes in mammalian cells, several Rabs have been reported to play crucial roles in osteoclast biogenesis and function. In this review, we aim to provide an update on recently described Rab GTPases, Rab11, Rab32, Rab44, and Rab38, as well as Rab7, Rab3D and Rab27A in osteoclast formation and function.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.