靶向Hippo信号的潜在癌症治疗进展。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-12-19 DOI:10.1042/BST20240244

Rui Zhu, Zhihan Jiao, Fa-Xing Yu

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引用次数: 0

摘要

几十年来对Hippo信号通路的研究极大地促进了我们对其在器官生长、组织再生和肿瘤发生中的作用的理解。Hippo通路在人类癌症中经常失调，被认为是一个重要的癌症信号通路。因此，Hippo通路代表了癌症治疗的理想分子靶点。本文将重点介绍靶向Hippo通路治疗癌症的最新进展，并讨论开发新治疗方式的潜在机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances towards potential cancer therapeutics targeting Hippo signaling.

Decades of research into the Hippo signaling pathway have greatly advanced our understanding of its roles in organ growth, tissue regeneration, and tumorigenesis. The Hippo pathway is frequently dysregulated in human cancers and is recognized as a prominent cancer signaling pathway. Hence, the Hippo pathway represents an ideal molecular target for cancer therapies. This review will highlight recent advancements in targeting the Hippo pathway for cancer treatment and discuss the potential opportunities for developing new therapeutic modalities.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.