通过N -烷基化-羟基化-酯交换级联反应的区域特异性烯烃氧化胺化

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2024-12-06 DOI:10.1002/adsc.202401365

Hong-Xia Zhang, Li-Gang Kou, Ya-Ru Gao, Qiong Jia, Yong-Qiang Wang

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引用次数: 0

摘要

本文报道了一种前所未有的简单无活性烯烃、偶氮化合物和水的级联反应，以生产有价值的多取代恶唑烷酮。该转化具有专一的区域选择性，反应条件温和，底物范围广。机理研究表明，这种转化经历了N -烷基化-羟基化-酯交换级联过程。这项研究不仅突破了烯烃基本双官能化的界限，而且为偶氮化合物开辟了新的化学途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Regiospecific Alkene Oxyamination via N‐Alkylation‐Hydroxylation‐Transesterification Cascades

An unprecedented cascade reaction of simple inactive alkenes, azo compounds and H2O to produce valuable poly‐substituted oxazolidinones is reported herein. The transformation possesses exclusive regioselectivity, and features mild reaction conditions and a broad substrate scope. Mechanistic studies indicated this transformation underwent a N‐alkylation‐hydroxylation‐transesterification cascade process. This research not only pushes the boundaries of the essential difunctionalization of alkenes but also exploits a new chemistry for azo compounds.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.