舌苔和唾液菌群对口腔癌发病的影响及白细胞介素-8的调节作用。

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-01-01 DOI:10.1016/j.cyto.2024.156821

Xiaotang Wang , Xiaona Song , Jiping Gao , Yunhui Ma , Tian Wang , Xiaoqi Chang , Shuxuan Shi , Yaqi Liu , Guohua Song

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引用次数: 0

摘要

背景：口腔菌群和炎症因子在口腔癌中起着至关重要的作用，但它们与口腔癌的关系尚未明确。方法：以口腔菌群为暴露因子，以口腔癌为结局因子，以炎症因子为中介因子。采用孟德尔随机化（Mendelian randomization， MR）分析口腔菌群与口腔癌的关系，并通过中介分析探索炎症因子的潜在中介作用。结果：舌苔中29种口腔菌群和唾液中22种口腔菌群与口腔癌发生风险增加有关。舌苔中的18种口腔菌群和唾液中的25种口腔菌群与口腔癌风险降低有关。白细胞介素-8 （Interleukin-8, IL8）在口腔菌群与口腔癌的关系中起中介作用，并与口腔癌发病风险增加有关。口腔菌群中的肉芽菌、链球菌、糖毒杆菌科和嗜血杆菌通过il - 8间接引起口腔癌。il - 8在口腔癌中表达升高，具有良好的诊断价值。口腔癌中il - 8相关基因与免疫细胞浸润密切相关。更重要的是，il - 8具有潜在的药用价值。结论：舌苔和唾液的口腔菌群与口腔癌密切相关，il - 8在口腔菌群与口腔癌的因果关系中起中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Impact of oral flora in tongue coating and saliva on oral cancer risk and the regulatory role of Interleukin-8

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Impact of oral flora in tongue coating and saliva on oral cancer risk and the regulatory role of Interleukin-8

Background

Oral flora and inflammatory factors play a crucial role in oral cancer, but the relationship between them and oral cancer has not been clearly established.

Methods

Oral flora served as exposure factor, oral cancer as outcome factor, and inflammatory factors as mediating factor. Mendelian randomization (MR) analysis was used to analyze the relationship between oral flora and oral cancer, and the potential mediating effect of inflammatory factors was explored through mediation analysis.

Results

29 kinds of oral flora in tongue coating and 22 kinds of oral flora in saliva were associated with increased risk of oral cancer. 18 species of oral flora in tongue coating and 25 species in saliva were associated with a reduced risk of oral cancer. Interleukin-8 (IL8) played a mediating role in the relationship between oral flora and oral cancer, and it was associated with an increased risk of oral cancer. Granulicatella, Streptococcus mitis, Saccharimonadaceae and Haemophilus in oral flora caused oral cancer indirectly through IL8. IL8 expression increased in oral cancer, which has good diagnostic value. IL8-related genes in oral cancer are closely associated with immune cell infiltration. What's more, IL8 has potential medicinal properties.

Conclusion

Oral flora of tongue coating and saliva is closely related to oral cancer, and IL8 plays a mediating role in the causal relationship between oral flora and oral cancer.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.