预防辐射和化学毒性：来自骨髓芯片的见解

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-12-05 DOI:10.1016/j.stem.2024.11.009

Milica Radisic

引用次数: 0

摘要

物种特异性差异促进了人类造血模型的发展。Georgescu等人提出了一种人类骨髓血管周围生态位的微流体模型来捕捉先天免疫细胞的动员。自动化培养和高含量分析，使辐射损伤和化疗剂量研究具有强大的洞察力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Preventing radiation and chemo toxicity: Insights from bone marrow-on-a-chip

Species-specific differences motivate the development of human hematopoiesis models. Georgescu et al.¹ present a microfluidic model of the human bone marrow perivascular niche to capture innate immune cell mobilization. Automated cultivation and high-content analysis for robust insights enabled studies of radiation injury and chemotherapy dosing.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.