Annalie Wentzel, Sihle E. Mabhida, Musawenkosi Ndlovu, Haskly Mokoena, Bevan Esterhuizen, Machoene D. Sekgala, Phiwayinkosi V. Dludla, André P. Kengne, Zandile J. Mchiza
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引用次数: 0
摘要
目的：本研究通过系统分析全球数据，探讨儿童和青少年肥胖代谢综合征（MetS）的流行趋势。此外，它的目的是比较区域差异和用于确定这一人口群体中有风险的亚人群的标准。方法：检索PubMed-Medline、Scopus和Web of Science三个主要数据库，检索时间自成立至2023年8月31日，共收录论文2432篇。我们纳入了报告肥胖儿童和青少年中MetS患病率的原始研究论文，而不考虑其地区和使用的MetS诊断标准。我们使用随机效应模型汇总患病率估计，以获得总体患病率，并对MetS标准和研究区域进行亚组分析。结果：我们纳入了57项研究，共计27,923名受试者。在不同的研究中，肥胖参与者的met总体患病率差异很大，从2.1%到74.4%不等，平均患病率为29.4%。一项包含57项研究的荟萃分析进一步支持了MetS的高患病率，该分析进一步加强了MetS高患病率的观察，显示总患病率为26% (95% CI: 0.22-0.30；i2 = 98%)。结论：肥胖儿童和青少年患MetS的风险增加。迫切需要加强对这一问题的关注，特别是在撒哈拉以南非洲等低收入和中等收入国家。
Prevalence of metabolic syndrome in children and adolescents with obesity: a systematic review and meta-analysis
Objective
This study investigated the prevalence trends of metabolic syndrome (MetS) in children and adolescents with obesity by systematically analyzing global data. Additionally, it aimed to compare regional disparities and criteria used to identify at-risk subpopulations among this demographic group.
Methods
We searched three major databases, i.e., PubMed-Medline, Scopus, and Web of Science, from inception to August 31, 2023, yielding 2432 articles. We included original research papers reporting MetS prevalence among children and adolescents with obesity, irrespective of their regions and MetS diagnostic criteria used. We aggregated prevalence estimates using random-effects models to obtain the overall prevalence and conducted subgroup analyses for MetS criteria and study regions.
Results
We included 57 studies, amounting to 27,923 participants. The overall prevalence of MetS in participants with obesity varied greatly across studies, ranging from 2.1% to 74.4%, with an average prevalence of 29.4%. This high prevalence of MetS was further supported by a meta-analysis comprising 57 studies that further strengthened the observation of a high prevalence of MetS, revealing an overall prevalence of 26% (95% CI: 0.22–0.30; I2 = 98%).
Conclusions
Children and adolescents with obesity face a heightened risk of developing MetS. There is a pressing need for heightened attention to this issue, particularly in low- and middle-income countries such as those in sub-Saharan Africa.
期刊介绍：
Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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