RAB39B x连锁帕金森病早期左旋多巴诱导的运动并发症。

IF 2.5 Q2 CLINICAL NEUROLOGY

Tremor and Other Hyperkinetic Movements Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI:10.5334/tohm.946

Laurane Mackels, David Aktan, Frédérique Depierreux

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引用次数: 0

摘要

背景：虽然左旋多巴可能对一些单基因帕金森病和帕金森症患者有益，但其他患者可能在接触后早期表现出异常反应。报告罕见遗传性帕金森病的治疗反应将有助于为特定患者亚群量身定制治疗方法。病例报告：我们报告了一例RAB39B x连锁帕金森病患者的治疗反应，该患者在左旋多巴治疗几个月内出现了运动和非运动并发症。讨论：严重和衰弱的左旋多巴诱导的并发症可以在x连锁帕金森病的治疗过程中很早就发生，突出了个体化治疗方法和罕见帕金森综合征随访的必要性。

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查看原文本刊更多论文

Early Levodopa-Induced Motor Complications in RAB39B X-Linked Parkinsonism.

Background: While levodopa may benefit some patients with monogenic Parkinson's Disease and parkinsonism, others may exhibit aberrant responses earlier after exposure. Reporting treatment responses in rare genetic parkinsonism will help tailor therapeutic approaches to specific patients subpopulations.

Case report: We report the therapeutic response in a patient with RAB39B X-linked parkinsonism, who exhibited motor and non-motor complications within a few months of Levodopa.

Discussion: Severe and debilitating Levodopa-induced complications can occur very early in the treatment course of X-linked parkinsonism, highlighting the need for an individualized therapeutic approach and follow-up in rare parkinsonian syndromes.

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来源期刊

Tremor and Other Hyperkinetic Movements CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

4.50%

发文量

审稿时长

6 weeks