血清总胆红素水平作为抗动脉粥样硬化机制的介质，并考虑吸烟状况。

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI:10.18332/tid/195378

Shigemasa Tani, Kazuhiro Imatake, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi

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引用次数: 0

摘要

吸烟是动脉粥样硬化性心血管疾病（ascvd）的重要危险因素。轻度升高的血清总胆红素（TSB）水平可以发挥抗动脉粥样硬化的作用，并可能调节炎症。我们探讨了TSB水平、吸烟和炎症之间的关系。方法：本横断面研究评估了2019年4月1日至2020年3月31日期间无ASCVD病史的健康筛查参与者。采用Kruskal-Wallis检验比较非吸烟者和吸烟者的TSB水平，并以TSB水平高于75百分位集为因变量，采用多变量logistic回归确定TSB水平的影响因素。进行中介分析以确定TSB水平是否介导吸烟与炎症之间的关联。结果：共有8337名参与者(平均年龄：46.6±13.0岁；58.9%男性)。吸烟者（n=1353）的TSB水平显著低于非吸烟者（n=6984）[中位数（IQR）： 0.72 (0.56-0.92) vs 0.76 (0.60-0.97) mg/dL]，结论：吸烟习惯相关的TSB水平较低可能与较高的炎症相关，从而增加ASCVD的风险。TSB可能调节炎症并发挥抗氧化作用。此外，戒烟可能导致更高的TSB水平和更低的炎症。

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Total serum bilirubin levels as mediators of anti-atherosclerosis mechanisms with consideration of smoking status.

Introduction: Cigarette smoking is a significant risk factor for atherosclerotic cardiovascular diseases (ASCVDs). Mildly elevated total serum bilirubin (TSB) levels can exert anti-atherosclerotic effects and may regulate inflammation. We explore the relationship between TSB levels, smoking, and inflammation.

Methods: This cross-sectional study evaluated health screening participants with no history of ASCVD between 1 April 2019 and 31 March 2020. TSB was compared between non-smokers and smokers using the Kruskal-Wallis test, and the influencing factors of TSB levels were identified using multivariable logistic regression with TSB levels above the 75th percentile set as the dependent variable. Mediation analysis was performed to determine whether TSB levels mediated the association between smoking and inflammation.

Results: A total of 8337 participants (mean age: 46.6 ± 13.0 years; 58.9% men) were included. TSB levels were significantly lower in smokers (n=1353) than in non-smokers (n=6984) [median (IQR): 0.72 (0.56-0.92) vs 0.76 (0.60-0.97) mg/dL, p<0.0001]. Multivariable logistic regression analysis demonstrated that smoking was an independent determinant of lower TSB levels (adjusted odds ratio, AOR=0.81; 95% CI: 0.70-0.93, p=0.003). Leukocyte counts and C-reactive protein levels significantly decreased as TSB levels increased (p<0.0001). Moreover, the relationship between the duration of smoking cessation and TSB levels showed a positive correlation. Mediation analysis indicated that cigarette smoking had significant indirect effects on higher leukocyte counts and higher CRP levels (coefficient=0.014; 95% CI: 0.008-0.021; and coefficient=0.002; 95% CI: 0.001-0.003, respectively].

Conclusions: Lower TSB levels related to a smoking habit may be associated with higher inflammation, thereby increasing the ASCVD risk. TSB may regulate inflammation and exert antioxidant effects. Furthermore, smoking cessation may lead to higher TSB levels and lower inflammation.

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.