S Graff, C Moermans, S Gerday, M Henket, V Paulus, F Guissard, R Louis, F Schleich
{"title":"随着时间的推移，血嗜酸性粒细胞计数和痰il - 8的增加与哮喘患者FEV1下降有关。","authors":"S Graff, C Moermans, S Gerday, M Henket, V Paulus, F Guissard, R Louis, F Schleich","doi":"10.1007/s00408-024-00760-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Asthma is associated with accelerated rate of FEV<sub>1</sub> decline.</p><p><strong>Objective: </strong>To determine predictive factors associated with accelerated FEV<sub>1</sub> decline in adult asthma and evaluate sputum cytokines as potential biomarkers for airflow decline.</p><p><strong>Methods: </strong>We recruited 125 asthmatics evaluated at the asthma clinic of Liège and reevaluated them at least 5 years later. Clinical, functional and inflammatory characteristics were compared between patients with accelerated decline (FEV<sub>1</sub> decline > 0.85% pred.y<sup>-1</sup>) and others. Predictive factors were highlighted with linear regression analysis. Sputum EGF, VEGF, FGF, IL5, IL8, TGF-β, and IgE levels were measured in 58 of these patients at both visits by Human XL cytokine Luminex Performance assay and Elisa.</p><p><strong>Results: </strong>Post-BD FEV<sub>1</sub> decline was 0.06 ± 2.44% pred.y<sup>-1</sup> in the overall population. Median (IQR) time between visits was 66 (62 - 86) months. The multivariable analysis showed that an increase in blood eosinophils over time (Δ BEC) (Reg. Coef. (95%CI): 0.002 (0.001 to 0.004), p = 0.005)) and onset of asthma (0.04 (0.003 to 0.07), p = 0.036) were independently associated with FEV<sub>1</sub> decline. IL8 levels measured at baseline were higher (499 (408-603) pg/ml, p = 0.0040) in patients with accelerated decline compared to others (143 (88-308) pg/ml).</p><p><strong>Conclusion: </strong>In this study, we have confirmed that an increase in blood eosinophil counts over a follow-up of at least 5 years and later onset of asthma are associated with accelerated annual FEV<sub>1</sub> decline. Moreover, high sputum IL8 levels could be a risk factor for accelerated decline in asthma patients.</p>","PeriodicalId":18163,"journal":{"name":"Lung","volume":"203 1","pages":"8"},"PeriodicalIF":4.6000,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608213/pdf/","citationCount":"0","resultStr":"{\"title\":\"Increase in Blood Eosinophil Count Over Time and Sputum IL8 are Associated with FEV<sub>1</sub> Decline in Asthma.\",\"authors\":\"S Graff, C Moermans, S Gerday, M Henket, V Paulus, F Guissard, R Louis, F Schleich\",\"doi\":\"10.1007/s00408-024-00760-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Asthma is associated with accelerated rate of FEV<sub>1</sub> decline.</p><p><strong>Objective: </strong>To determine predictive factors associated with accelerated FEV<sub>1</sub> decline in adult asthma and evaluate sputum cytokines as potential biomarkers for airflow decline.</p><p><strong>Methods: </strong>We recruited 125 asthmatics evaluated at the asthma clinic of Liège and reevaluated them at least 5 years later. Clinical, functional and inflammatory characteristics were compared between patients with accelerated decline (FEV<sub>1</sub> decline > 0.85% pred.y<sup>-1</sup>) and others. Predictive factors were highlighted with linear regression analysis. Sputum EGF, VEGF, FGF, IL5, IL8, TGF-β, and IgE levels were measured in 58 of these patients at both visits by Human XL cytokine Luminex Performance assay and Elisa.</p><p><strong>Results: </strong>Post-BD FEV<sub>1</sub> decline was 0.06 ± 2.44% pred.y<sup>-1</sup> in the overall population. Median (IQR) time between visits was 66 (62 - 86) months. The multivariable analysis showed that an increase in blood eosinophils over time (Δ BEC) (Reg. Coef. (95%CI): 0.002 (0.001 to 0.004), p = 0.005)) and onset of asthma (0.04 (0.003 to 0.07), p = 0.036) were independently associated with FEV<sub>1</sub> decline. IL8 levels measured at baseline were higher (499 (408-603) pg/ml, p = 0.0040) in patients with accelerated decline compared to others (143 (88-308) pg/ml).</p><p><strong>Conclusion: </strong>In this study, we have confirmed that an increase in blood eosinophil counts over a follow-up of at least 5 years and later onset of asthma are associated with accelerated annual FEV<sub>1</sub> decline. Moreover, high sputum IL8 levels could be a risk factor for accelerated decline in asthma patients.</p>\",\"PeriodicalId\":18163,\"journal\":{\"name\":\"Lung\",\"volume\":\"203 1\",\"pages\":\"8\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-11-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608213/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lung\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00408-024-00760-9\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00408-024-00760-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Increase in Blood Eosinophil Count Over Time and Sputum IL8 are Associated with FEV1 Decline in Asthma.
Background: Asthma is associated with accelerated rate of FEV1 decline.
Objective: To determine predictive factors associated with accelerated FEV1 decline in adult asthma and evaluate sputum cytokines as potential biomarkers for airflow decline.
Methods: We recruited 125 asthmatics evaluated at the asthma clinic of Liège and reevaluated them at least 5 years later. Clinical, functional and inflammatory characteristics were compared between patients with accelerated decline (FEV1 decline > 0.85% pred.y-1) and others. Predictive factors were highlighted with linear regression analysis. Sputum EGF, VEGF, FGF, IL5, IL8, TGF-β, and IgE levels were measured in 58 of these patients at both visits by Human XL cytokine Luminex Performance assay and Elisa.
Results: Post-BD FEV1 decline was 0.06 ± 2.44% pred.y-1 in the overall population. Median (IQR) time between visits was 66 (62 - 86) months. The multivariable analysis showed that an increase in blood eosinophils over time (Δ BEC) (Reg. Coef. (95%CI): 0.002 (0.001 to 0.004), p = 0.005)) and onset of asthma (0.04 (0.003 to 0.07), p = 0.036) were independently associated with FEV1 decline. IL8 levels measured at baseline were higher (499 (408-603) pg/ml, p = 0.0040) in patients with accelerated decline compared to others (143 (88-308) pg/ml).
Conclusion: In this study, we have confirmed that an increase in blood eosinophil counts over a follow-up of at least 5 years and later onset of asthma are associated with accelerated annual FEV1 decline. Moreover, high sputum IL8 levels could be a risk factor for accelerated decline in asthma patients.
期刊介绍：
Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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