Amna Munsaf, Muhammad Naeem Ahmed, Ihsan Ul Haq, Bilal Akram, Mahmoud A A Ibrahim
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Cefixime-Infused Green ZnO Nanoplatelets With Enhanced Biological Potential.
The escalating resistance to traditional antibiotics causes a significant hazard to public health, demanding innovative antimicrobial strategies. This study introduces cefixime-infused green-synthesized zinc oxide nanoplatelets (ZnO NPts) highlighting their enhanced biological potential. The successful formation of ZnO NPts and their subsequent infusion with cefixime were confirmed using various characterization techniques: UV-visible spectroscopy, Fourier transform infrared spectroscopy, x-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, and dynamic light scattering. Comparing cefixime-functionalized ZnO NPts with pure ZnO and cefixime alone, biological assessments revealed that the former exhibited stronger antifungal activity against the tested strains. Moreover, these NPts demonstrated the highest cytotoxicity in tests with Artemia salina larvae and pronounced antioxidant activity in TAC, TRP, and DPPH assays. These findings emphasize the significant potential of cefixime-infused ZnO NPts for various biomedical applications, offering enhanced antifungal, cytotoxic, and antioxidant properties.
期刊介绍:
Microscopy Research and Technique (MRT) publishes articles on all aspects of advanced microscopy original architecture and methodologies with applications in the biological, clinical, chemical, and materials sciences. Original basic and applied research as well as technical papers dealing with the various subsets of microscopy are encouraged. MRT is the right form for those developing new microscopy methods or using the microscope to answer key questions in basic and applied research.