熊果酸在结直肠癌中的作用机制、现状、挑战及未来研究方向

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Pharmacological Reports Pub Date : 2025-02-01 Epub Date: 2024-12-02 DOI:10.1007/s43440-024-00684-4

Huici Zhang, Xiaoyu Zhang, Xijun Ma, Xuan Wang

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引用次数: 0

摘要

结直肠癌（CRC）是全球第三大流行癌症，约占所有癌症病例的10%，是全球癌症相关死亡的第二大原因。熊果酸（UA）是一种被广泛研究的五环三萜，因其对恶性肿瘤的潜在治疗作用而引起了研究人员和临床医生的广泛关注。多项研究证实，UA通过多种机制抑制肿瘤细胞增殖、诱导分化和凋亡、抑制侵袭、阻碍肿瘤血管生成。然而，专门针对UA抗CRC作用的研究仍然有限，并且对其在CRC中的潜在机制的系统综述很少。本研究旨在全面综述UA对CRC的作用机制，为研究人员和临床医生提供有价值的见解和参考。

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Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions.

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally, contributing to approximately 10% of all cancer cases and representing the second leading cause of cancer-related mortality worldwide. Ursolic acid (UA), a widely studied pentacyclic triterpenoid, has attracted substantial attention from researchers and clinicians due to its potential therapeutic effects against malignant tumors. Multiple studies have confirmed that UA inhibits tumor cell proliferation, induces differentiation and apoptosis, suppresses invasion, and impedes tumor angiogenesis via diverse mechanisms. However, research specifically addressing UA's anti-CRC effects remains limited, and systematic reviews of its underlying mechanisms in CRC are scarce. This study seeks to provide a comprehensive review of UA's mechanisms of action against CRC, offering valuable insights and references for researchers and clinicians.

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来源期刊

Pharmacological Reports 医学-药学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Pharmacological Reports publishes articles concerning all aspects of pharmacology, dealing with the action of drugs at a cellular and molecular level, and papers on the relationship between molecular structure and biological activity as well as reports on compounds with well-defined chemical structures. Pharmacological Reports is an open forum to disseminate recent developments in: pharmacology, behavioural brain research, evidence-based complementary biochemical pharmacology, medicinal chemistry and biochemistry, drug discovery, neuro-psychopharmacology and biological psychiatry, neuroscience and neuropharmacology, cellular and molecular neuroscience, molecular biology, cell biology, toxicology. Studies of plant extracts are not suitable for Pharmacological Reports.