{"title":"寻找平衡：帕金森病患者体位性低血压的药物治疗综述。","authors":"Ugene Sano","doi":"10.3928/00989134-20241113-02","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Orthostatic hypotension (OH) is a common manifestation of Parkinson's disease (PD). Factors including autonomic dysfunction from the disease, use of PD medications, comorbidities, and aging can contribute to an increased risk of OH, which can be detrimental to patients' quality of life. Maintaining a fine balance to prevent harm related to OH and retain the benefit medications used to treat PD is crucial. The current article reviews various considerations in selecting and adjusting pharmacotherapy for OH in patients with PD.</p><p><strong>Method: </strong>Current evidence and guidance on pharmacological strategies of OH in patients with PD were reviewed.</p><p><strong>Results: </strong>Current strategies include medication regimen review and adjustment of patient's medication regimen and single or combination pharmacotherapy (midodrine, droxidopa, fludrocortisone, pyridostigmine) used in addition to nonpharmacological strategies.</p><p><strong>Conclusion: </strong>A patient-specific approach is needed to address OH in PD. Larger studies on safety and management of OH in PD are recommended given paucity of studies. [<i>Journal of Gerontological Nursing, 50</i>(12), 5-10.].</p>","PeriodicalId":15848,"journal":{"name":"Journal of gerontological nursing","volume":"50 12","pages":"5-10"},"PeriodicalIF":1.1000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Finding the Balance: Review of Pharmacological Management of Orthostatic Hypotension in Patients With Parkinson's Disease.\",\"authors\":\"Ugene Sano\",\"doi\":\"10.3928/00989134-20241113-02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Orthostatic hypotension (OH) is a common manifestation of Parkinson's disease (PD). Factors including autonomic dysfunction from the disease, use of PD medications, comorbidities, and aging can contribute to an increased risk of OH, which can be detrimental to patients' quality of life. Maintaining a fine balance to prevent harm related to OH and retain the benefit medications used to treat PD is crucial. The current article reviews various considerations in selecting and adjusting pharmacotherapy for OH in patients with PD.</p><p><strong>Method: </strong>Current evidence and guidance on pharmacological strategies of OH in patients with PD were reviewed.</p><p><strong>Results: </strong>Current strategies include medication regimen review and adjustment of patient's medication regimen and single or combination pharmacotherapy (midodrine, droxidopa, fludrocortisone, pyridostigmine) used in addition to nonpharmacological strategies.</p><p><strong>Conclusion: </strong>A patient-specific approach is needed to address OH in PD. Larger studies on safety and management of OH in PD are recommended given paucity of studies. [<i>Journal of Gerontological Nursing, 50</i>(12), 5-10.].</p>\",\"PeriodicalId\":15848,\"journal\":{\"name\":\"Journal of gerontological nursing\",\"volume\":\"50 12\",\"pages\":\"5-10\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of gerontological nursing\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/00989134-20241113-02\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of gerontological nursing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/00989134-20241113-02","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Finding the Balance: Review of Pharmacological Management of Orthostatic Hypotension in Patients With Parkinson's Disease.
Purpose: Orthostatic hypotension (OH) is a common manifestation of Parkinson's disease (PD). Factors including autonomic dysfunction from the disease, use of PD medications, comorbidities, and aging can contribute to an increased risk of OH, which can be detrimental to patients' quality of life. Maintaining a fine balance to prevent harm related to OH and retain the benefit medications used to treat PD is crucial. The current article reviews various considerations in selecting and adjusting pharmacotherapy for OH in patients with PD.
Method: Current evidence and guidance on pharmacological strategies of OH in patients with PD were reviewed.
Results: Current strategies include medication regimen review and adjustment of patient's medication regimen and single or combination pharmacotherapy (midodrine, droxidopa, fludrocortisone, pyridostigmine) used in addition to nonpharmacological strategies.
Conclusion: A patient-specific approach is needed to address OH in PD. Larger studies on safety and management of OH in PD are recommended given paucity of studies. [Journal of Gerontological Nursing, 50(12), 5-10.].
期刊介绍：
The Journal of Gerontological Nursing is a monthly, peer-reviewed journal publishing clinically relevant original articles on the practice of gerontological nursing across the continuum of care in a variety of health care settings, for more than 40 years.
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