{"title":"高龄对雄性大鼠心电图参数、血脂和氧化还原平衡的影响：长期食用肉桂的作用。","authors":"M Salari, S Nakhaee, Z Ataie, K Farrokhfall","doi":"10.22099/IJVR.2024.47879.6948","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress damages biological molecules and plays a role in aging-related cardiovascular diseases. <i>Cinnamomum zeylanicum</i> is a major source of antioxidants that may work against age-related cardiovascular changes.</p><p><strong>Aims: </strong>This study aimed to assess the changes in electrocardiography and lipid profile as well as indicators of the oxidant-antioxidant system with advanced age in rats. Also, the possible beneficial effect of cinnamon on these parameters has been investigated.</p><p><strong>Methods: </strong>In this experimental study, thirty male Sprague-Dawley rats were randomly assigned to five groups. The control groups of 12, and 20 months received a normal chow diet, while the investigation group was given a control diet mixed with cinnamon powder (1% of the diet). Also, a control group of 3-month-old rats was considered for assessment of age effects. Systolic blood pressure (SBP), ECG, serum lipid profiles, and heart oxidative stress markers were compared in different groups at the end of the study.</p><p><strong>Results: </strong>Systolic BP, serum cholesterol, HDL and LDL-cholesterol, the heart level of malondialdehyde (MDA) and nitric oxide metabolites (NOx), the ECG parameters including QRS duration, PR, T<sub>peak</sub>-T<sub>end</sub>, and QT interval, as well as QTc increased significantly in older rats (20 months vs 3 months). Cinnamon consumption restored MDA levels, QRS duration, and T<sub>peak</sub>-T<sub>end</sub> interval in aging hearts. Whereas, neither aging nor cinnamon consumption could affect SOD activity.</p><p><strong>Conclusion: </strong>The results demonstrated that aging is associated with ECG alteration, oxidative stress, and an increase in TC, LDL, and HDL cholesterol. Cinnamon improved electrical heart activity in aged rats (20 months) by restoration of QRS duration and T<sub>peak</sub>-T<sub>end</sub> interval as well as amelioration of heart oxidative stress. Altogether, cinnamon supplementation has a cardioprotective effects during aging in rats.</p>","PeriodicalId":14629,"journal":{"name":"Iranian journal of veterinary research","volume":"25 2","pages":"107-116"},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608530/pdf/","citationCount":"0","resultStr":"{\"title\":\"The effects of advanced age on electrocardiographic parameters, lipid profile and redox balance in male rats: role of long-term cinnamon consumption.\",\"authors\":\"M Salari, S Nakhaee, Z Ataie, K Farrokhfall\",\"doi\":\"10.22099/IJVR.2024.47879.6948\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Oxidative stress damages biological molecules and plays a role in aging-related cardiovascular diseases. <i>Cinnamomum zeylanicum</i> is a major source of antioxidants that may work against age-related cardiovascular changes.</p><p><strong>Aims: </strong>This study aimed to assess the changes in electrocardiography and lipid profile as well as indicators of the oxidant-antioxidant system with advanced age in rats. Also, the possible beneficial effect of cinnamon on these parameters has been investigated.</p><p><strong>Methods: </strong>In this experimental study, thirty male Sprague-Dawley rats were randomly assigned to five groups. The control groups of 12, and 20 months received a normal chow diet, while the investigation group was given a control diet mixed with cinnamon powder (1% of the diet). Also, a control group of 3-month-old rats was considered for assessment of age effects. Systolic blood pressure (SBP), ECG, serum lipid profiles, and heart oxidative stress markers were compared in different groups at the end of the study.</p><p><strong>Results: </strong>Systolic BP, serum cholesterol, HDL and LDL-cholesterol, the heart level of malondialdehyde (MDA) and nitric oxide metabolites (NOx), the ECG parameters including QRS duration, PR, T<sub>peak</sub>-T<sub>end</sub>, and QT interval, as well as QTc increased significantly in older rats (20 months vs 3 months). Cinnamon consumption restored MDA levels, QRS duration, and T<sub>peak</sub>-T<sub>end</sub> interval in aging hearts. Whereas, neither aging nor cinnamon consumption could affect SOD activity.</p><p><strong>Conclusion: </strong>The results demonstrated that aging is associated with ECG alteration, oxidative stress, and an increase in TC, LDL, and HDL cholesterol. Cinnamon improved electrical heart activity in aged rats (20 months) by restoration of QRS duration and T<sub>peak</sub>-T<sub>end</sub> interval as well as amelioration of heart oxidative stress. Altogether, cinnamon supplementation has a cardioprotective effects during aging in rats.</p>\",\"PeriodicalId\":14629,\"journal\":{\"name\":\"Iranian journal of veterinary research\",\"volume\":\"25 2\",\"pages\":\"107-116\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608530/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian journal of veterinary research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.22099/IJVR.2024.47879.6948\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.22099/IJVR.2024.47879.6948","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
The effects of advanced age on electrocardiographic parameters, lipid profile and redox balance in male rats: role of long-term cinnamon consumption.
Background: Oxidative stress damages biological molecules and plays a role in aging-related cardiovascular diseases. Cinnamomum zeylanicum is a major source of antioxidants that may work against age-related cardiovascular changes.
Aims: This study aimed to assess the changes in electrocardiography and lipid profile as well as indicators of the oxidant-antioxidant system with advanced age in rats. Also, the possible beneficial effect of cinnamon on these parameters has been investigated.
Methods: In this experimental study, thirty male Sprague-Dawley rats were randomly assigned to five groups. The control groups of 12, and 20 months received a normal chow diet, while the investigation group was given a control diet mixed with cinnamon powder (1% of the diet). Also, a control group of 3-month-old rats was considered for assessment of age effects. Systolic blood pressure (SBP), ECG, serum lipid profiles, and heart oxidative stress markers were compared in different groups at the end of the study.
Results: Systolic BP, serum cholesterol, HDL and LDL-cholesterol, the heart level of malondialdehyde (MDA) and nitric oxide metabolites (NOx), the ECG parameters including QRS duration, PR, Tpeak-Tend, and QT interval, as well as QTc increased significantly in older rats (20 months vs 3 months). Cinnamon consumption restored MDA levels, QRS duration, and Tpeak-Tend interval in aging hearts. Whereas, neither aging nor cinnamon consumption could affect SOD activity.
Conclusion: The results demonstrated that aging is associated with ECG alteration, oxidative stress, and an increase in TC, LDL, and HDL cholesterol. Cinnamon improved electrical heart activity in aged rats (20 months) by restoration of QRS duration and Tpeak-Tend interval as well as amelioration of heart oxidative stress. Altogether, cinnamon supplementation has a cardioprotective effects during aging in rats.
期刊介绍：
The Iranian Journal of Veterinary Research(IJVR) is published quarterly in 4 issues. The aims of this journal are to improve and expand knowledge in all veterinary fields. It is an international journal indexed by the Thomson Institute for Scientific Information (ISI), Elsevier, Scopus, CAB International, Veterinary Bulletin and several other international databases. Research papers and reports on a wide range of veterinary topics are published in the journal after being evaluated by expert reviewers.The Editor-in-Chief is responsible for the editorial content of the journal—including peer-reviewed manuscripts—and the timing of its publication.
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