社区获得性肺炎中菌血症的患病率和危险因素：系统回顾和荟萃分析。

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-02-01 DOI:10.1016/j.ijid.2024.107312

Shanshan Wu , Lin Chen , Xiaoyan zhang , Jiali Fan , Fajuan Tang , Dongqiong Xiao

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引用次数: 0

摘要

背景：菌血症是社区获得性肺炎（CAP）患者的一个重要并发症。然而，目前缺乏系统的研究来确定CAP患者中菌血症的确切患病率和危险因素。方法：检索PubMed、Cochrane Library、Embase和Web of Science数据库，检索截至2024年4月21日已发表的关于CAP合并菌血症患病率或危险因素的研究。采用NOS量表评价研究质量，META过程采用R语言进行。结果：22项研究共纳入58,342例CAP患者。在这些患者中，29610人接受了血培养检查，2332人血培养结果呈阳性。meta分析汇总结果显示，CAP患者的菌血症发生率为5.1% （95%CI: 3.6-6.8%）。未成年人中共菌血症的患病率为3.1% (95% CI: 1.5-5.1%)，成人中为6.9% （95% CI: 5.2%-8.8%）。最常见的病原菌为肺炎链球菌、金黄色葡萄球菌。此外，对原始研究的总结发现，CAP患者菌血症的危险因素是多种多样的。结论：CAP患者菌血症的发生率值得重视。迫切需要建立更具体的细菌筛选方案。

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Prevalence and risk factors for bacteremia in community-acquired pneumonia: A systematic review and meta-analysis

Background

Bacteremia represents a significant complication in patients with community-acquired pneumonia (CAP). Nonetheless, there is currently a dearth of systematic research that determines the precise prevalence and risk factors of bacteremia in CAP patients.

Methods

PubMed, Cochrane Library, Embase, and Web of Science databases were searched for published studies on the prevalence or risk factors for CAP with bacteremia up to April 21, 2024. The NOS scale was utilized to appraise the study quality, and the META process was carried out in R language.

Results

58,342 CAP patients were enrolled in 22 studies. Of these patients, 29,610 underwent blood culture tests, and 2332 patients had positive blood culture results. Meta-analysis pooled results showed that the incidence of bacteremia was 5.1% (95% CI: 3.6-6.8%) in CAP patients. The prevalence of co-bacteremia was 3.1% (95% CI: 1.5-5.1%) in minors and 6.9% (95% CI: 5.2%-8.8%) in adults. The most common pathogens of CAP were Streptococcus pneumoniae, Staphylococcus aureus. In addition, a summary of the original studies found that the risk factors for bacteremia in CAP patients were diverse and varied.

Conclusions

The incidence of bacteremia in CAP patients warrants significant attention. There is a pressing need to establish more specific bacterial screening protocols.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.