基于SCORE算法的动脉粥样硬化性心血管疾病风险和基于临床前动脉粥样硬化斑块的重新分类。

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

International Angiology Pub Date : 2024-10-01 DOI:10.23736/S0392-9590.24.05248-9

Andrew N Nicolaides, Andrie G Panayiotou, Maura B Griffin, Theodosis Tyllis, Efthyvoulos Kyriacou, Costantinos Avraamides, Dawn Bond, Niki Georgiou, Despo Ierodiakonou, Christiana A Demetriou, Richard M Martin

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引用次数: 0

摘要

背景：本研究的目的是确定超声检测的颈动脉和股总分叉斑块（NBP）数量对SCORE算法获得的动脉粥样硬化性心血管疾病（ASCVD）风险重分类的有效性。数据来自塞浦路斯动脉粥样硬化流行病学研究的1000名无ASCVD患者。方法：在基于SCORE算法和基线数据的每个预测ASCVD风险等级（低、中、高）中，根据NBP观察到的10年亚组风险对参与者进行重新分类。结果：在平均15.2±4.9年的随访期间，共发生222例ASCVD事件。在每个预测的风险类别中，观察到的10年ASCVD事件风险在存在斑块的1、2、3和4分岔的亚组中逐渐增加(结论：结果表明，易于检测的NBP是ASCVD事件的独立预测因子，可以通过提高预测的SCORE风险来将个体重新划分为不同的风险类别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Atherosclerotic cardiovascular disease risk based on SCORE algorithms and reclassification based on preclinical atherosclerotic plaques.

Background: The aim of this study was to determine the efficacy of the number of carotid and common femoral bifurcations with plaque (NBP) detected by ultrasound in reclassifying atherosclerotic cardiovascular disease (ASCVD) risk obtained from SCORE algorithms. Data from the cohort of 1000 individuals free from ASCVD in the Cyprus Epidemiological Study on Atherosclerosis was used.

Methods: In each predicted ASCVD risk class (low, moderate, high) based on SCORE algorithms and baseline data, the observed 10-year risk of subgroups according to the NBP was used to reclassify participants.

Results: There were 222 ASCVD events during a mean follow-up of 15.2±4.9 years. In each predicted risk class, the observed 10-year ASCVD event risk increased progressively in the subgroups across the presence of 1, 2, 3 and 4 bifurcations with plaque (P<0.001); Hazard Ratios (crude and adjusted for conventional risk factors) also increased progressively (P<0.001). There was a correct down classification in 152 and correct up classification in 99 participants. Total correct reclassification improvement was in 251 (25.1%).

Conclusions: The results demonstrate that the NBP which is easy to detect is an independent predictor of ASCVD events and can be used to reclassify individuals into a different risk class by improving on the predicted SCORE risk.

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来源期刊

International Angiology 医学-外周血管病

CiteScore

2.80

自引率

28.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Angiology publishes scientific papers on angiology. Manuscripts may be submitted in the form of editorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work. Duties and responsibilities of all the subjects involved in the editorial process are summarized at Publication ethics. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors (ICMJE).