抗着丝粒抗体存在下无硬指的指性坏疽：硬皮病的一种独特表现。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2024-12-12 DOI:10.1016/j.ijmmb.2024.100769

Urvashi Suman, Lata Sheoran, Vikas Manchanda, Sonal Saxena

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引用次数: 0

摘要

结缔组织疾病（CTD）中，与抗着丝粒抗体（ACA）相关的周围血管疾病通常伴有硬化。在没有雷诺氏现象或血管危险因素的情况下，aca相关的指部坏死是很少见的。我们报告一个60岁的非吸烟，非糖尿病女性ACA和孤立的手指坏死没有任何其他特征的CTD。本病例强调了考虑自身免疫对指骨坏死发展的重要性，即使没有任何可识别的CTD。它强调需要考虑aca相关的指坏疽被视为硬皮病自身免疫性疾病的一个不同的实体。

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Digital gangrene without sclerodactyly in the presence of anticentromere antibodies: A unique presentation of scleroderma.

Peripheral vascular disorders associated with anti-centromere antibody (ACA) present generally with sclerodactyly in connective tissue disorders (CTD). It is unusual for ACA-associated digital necrosis to develop without preexisting raynaud's phenomena or vascular risk factors. We report a novel case of a 60-year-old non-smoker, non-diabetic woman with ACA and isolated finger necrosis without any other features of CTD. This case underscores the importance of considering an autoimmune contribution to the development of digital necrosis even without any identifiable CTD. It highlights the need to consider ACA-associated digital gangrene to be considered as a distinct entity of an autoimmune disorder from scleroderma.

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.