P.Y. Le Pennec, M.T. Klein, M. Le Besnerais, G. Tsikas, F. Champomier, D. Goossens, Ph. Rouger
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Immunological characterization of 21 human anti-Rh (D) monoclonal antibodies
In this work we studied 21 human monoclonal antibodies (MABs) which appeared during the screening tests to have an anti-Rh (D) specificity. These antibodies were then tested especially by agglutination techniques using a panel of human red blood cells RBC of common and rare phenotypes in order to:
1 -
Confirm their specificity
2 -
Investigate their reactivity with Rh variants
3 -
Determine their in vitro potency (titre and quantitation) using various techniques.
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