Süleyman Köken, Ersin Akşam, Rehber Marşil, Fatma Şimşek, Tunahan Berk Başol
{"title":"透明质酸和透明质酸酶注射对皮肤组织学影响的实验研究。","authors":"Süleyman Köken, Ersin Akşam, Rehber Marşil, Fatma Şimşek, Tunahan Berk Başol","doi":"10.1097/DSS.0000000000004512","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Nonsurgical facial rejuvenation procedures are currently among the most popular areas of plastic, reconstructive, and aesthetic surgery. The goal of this study is to identify the effects of simultaneous hyaluronic acid and hyaluronidase injections into animal skin. This study is the first animal study in the literature showing the effects of hyaluronic acid and hyaluronidase simultaneous injection on skin.</p><p><strong>Methods: </strong>The study included 15 male and 15 female Wistar Albino rats. Four different areas were determined on the backs of the rats: a control area, an area for injection with hyaluronic acid, an area for injection with hyaluronic acid with hyaluronidase, and an area for injection with hyaluronidase only. The experiment was terminated at different times in these groups. After sacrification, the 4 regions were compared with each other under light microscope.</p><p><strong>Results: </strong>The results of this study demonstrate increases in dermis thickness, collagen density, and extracellular matrix density with injection of hyaluronic acid (81% vs 69.1%, p < .05), and hyaluronidase appears to antagonize these effects (52.5% vs 59.17%, p < .05).</p><p><strong>Conclusion: </strong>Hyaluronic acid injections have positive effects on animal skin, while hyaluronidase can antagonize these effects. When hyaluronic acid and hyaluronidase are injected simultaneously into the animal skin, it is observed that the antagonizing effect of hyaluronidase is dominant from the first moment.</p>","PeriodicalId":11289,"journal":{"name":"Dermatologic Surgery","volume":" ","pages":"497-504"},"PeriodicalIF":2.5000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Histological Effects of Hyaluronic Acid and Hyaluronidase Injections on Skin: An Experimental Study.\",\"authors\":\"Süleyman Köken, Ersin Akşam, Rehber Marşil, Fatma Şimşek, Tunahan Berk Başol\",\"doi\":\"10.1097/DSS.0000000000004512\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Nonsurgical facial rejuvenation procedures are currently among the most popular areas of plastic, reconstructive, and aesthetic surgery. The goal of this study is to identify the effects of simultaneous hyaluronic acid and hyaluronidase injections into animal skin. This study is the first animal study in the literature showing the effects of hyaluronic acid and hyaluronidase simultaneous injection on skin.</p><p><strong>Methods: </strong>The study included 15 male and 15 female Wistar Albino rats. Four different areas were determined on the backs of the rats: a control area, an area for injection with hyaluronic acid, an area for injection with hyaluronic acid with hyaluronidase, and an area for injection with hyaluronidase only. The experiment was terminated at different times in these groups. After sacrification, the 4 regions were compared with each other under light microscope.</p><p><strong>Results: </strong>The results of this study demonstrate increases in dermis thickness, collagen density, and extracellular matrix density with injection of hyaluronic acid (81% vs 69.1%, p < .05), and hyaluronidase appears to antagonize these effects (52.5% vs 59.17%, p < .05).</p><p><strong>Conclusion: </strong>Hyaluronic acid injections have positive effects on animal skin, while hyaluronidase can antagonize these effects. When hyaluronic acid and hyaluronidase are injected simultaneously into the animal skin, it is observed that the antagonizing effect of hyaluronidase is dominant from the first moment.</p>\",\"PeriodicalId\":11289,\"journal\":{\"name\":\"Dermatologic Surgery\",\"volume\":\" \",\"pages\":\"497-504\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatologic Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/DSS.0000000000004512\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologic Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/DSS.0000000000004512","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
The Histological Effects of Hyaluronic Acid and Hyaluronidase Injections on Skin: An Experimental Study.
Background: Nonsurgical facial rejuvenation procedures are currently among the most popular areas of plastic, reconstructive, and aesthetic surgery. The goal of this study is to identify the effects of simultaneous hyaluronic acid and hyaluronidase injections into animal skin. This study is the first animal study in the literature showing the effects of hyaluronic acid and hyaluronidase simultaneous injection on skin.
Methods: The study included 15 male and 15 female Wistar Albino rats. Four different areas were determined on the backs of the rats: a control area, an area for injection with hyaluronic acid, an area for injection with hyaluronic acid with hyaluronidase, and an area for injection with hyaluronidase only. The experiment was terminated at different times in these groups. After sacrification, the 4 regions were compared with each other under light microscope.
Results: The results of this study demonstrate increases in dermis thickness, collagen density, and extracellular matrix density with injection of hyaluronic acid (81% vs 69.1%, p < .05), and hyaluronidase appears to antagonize these effects (52.5% vs 59.17%, p < .05).
Conclusion: Hyaluronic acid injections have positive effects on animal skin, while hyaluronidase can antagonize these effects. When hyaluronic acid and hyaluronidase are injected simultaneously into the animal skin, it is observed that the antagonizing effect of hyaluronidase is dominant from the first moment.
期刊介绍：
Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including:
-Ambulatory phlebectomy-
Blepharoplasty-
Body contouring-
Chemical peels-
Cryosurgery-
Curettage and desiccation-
Dermabrasion-
Excision and closure-
Flap Surgery-
Grafting-
Hair restoration surgery-
Injectable neuromodulators-
Laser surgery-
Liposuction-
Microdermabrasion-
Microlipoinjection-
Micropigmentation-
Mohs micrographic surgery-
Nail surgery-
Phlebology-
Sclerotherapy-
Skin cancer surgery-
Skin resurfacing-
Soft-tissue fillers.
Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.
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