{"title":"体力活动、最大摄氧量和脂肪素对BMI和慢性炎症关系的影响。","authors":"Liqiang Su, Shouzhi Wu, Jinmei Fu, Shunli Sun","doi":"10.2147/DMSO.S473266","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the relationship between BMI and chronic inflammation and to investigate the interaction and mediation of physical activity (PA), cardiopulmonary function, and visfatin.</p><p><strong>Methods: </strong>A total of 119 participants were included in the study, 60 in the obesity group, 30 in the normal weight group, and 29 in the overweight group. PA, VO<sub>2max</sub>, visfatin, high-sensitivity C-reactive protein (hs-CRP), and four blood lipid indices (TC, TG, HDLC, LDLC) were analyzed. Regression analysis was used to understand the effect of BMI on chronic inflammation. Covariate analysis was conducted to screen effective covariates affecting BMI to predict chronic inflammation and test the interaction and intermediary role of effective covariates.</p><p><strong>Results: </strong>The increase in BMI could aggravate chronic inflammation. PA, VO<sub>2max</sub>, and visfatin had interactive effects on BMI affecting chronic inflammation, and visfatin played an intermediary role in BMI affecting chronic inflammation. The effect value of BMI on chronic inflammation in terms of low PA was 3.5 times higher than that of high PA, that of low VO<sub>2max</sub> was 2.8 times higher than that of high VO<sub>2max</sub>, and that of high visfatin was 3.65 times higher than that of low visfatin. Approximately 19.35% of the effect was mediated by visfatin.</p><p><strong>Conclusion: </strong>An increase in BMI can aggravate chronic inflammation. Increases in PA and VO<sub>2max</sub> can alleviate chronic inflammation, and visfatin plays a positive mediating role.</p>","PeriodicalId":11116,"journal":{"name":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","volume":"17 ","pages":"4489-4500"},"PeriodicalIF":2.8000,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607996/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of Physical Activity, VO<sub>2max</sub>, and Visfatin on Relationship Between BMI and Chronic Inflammation.\",\"authors\":\"Liqiang Su, Shouzhi Wu, Jinmei Fu, Shunli Sun\",\"doi\":\"10.2147/DMSO.S473266\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aims to explore the relationship between BMI and chronic inflammation and to investigate the interaction and mediation of physical activity (PA), cardiopulmonary function, and visfatin.</p><p><strong>Methods: </strong>A total of 119 participants were included in the study, 60 in the obesity group, 30 in the normal weight group, and 29 in the overweight group. PA, VO<sub>2max</sub>, visfatin, high-sensitivity C-reactive protein (hs-CRP), and four blood lipid indices (TC, TG, HDLC, LDLC) were analyzed. Regression analysis was used to understand the effect of BMI on chronic inflammation. Covariate analysis was conducted to screen effective covariates affecting BMI to predict chronic inflammation and test the interaction and intermediary role of effective covariates.</p><p><strong>Results: </strong>The increase in BMI could aggravate chronic inflammation. PA, VO<sub>2max</sub>, and visfatin had interactive effects on BMI affecting chronic inflammation, and visfatin played an intermediary role in BMI affecting chronic inflammation. The effect value of BMI on chronic inflammation in terms of low PA was 3.5 times higher than that of high PA, that of low VO<sub>2max</sub> was 2.8 times higher than that of high VO<sub>2max</sub>, and that of high visfatin was 3.65 times higher than that of low visfatin. Approximately 19.35% of the effect was mediated by visfatin.</p><p><strong>Conclusion: </strong>An increase in BMI can aggravate chronic inflammation. Increases in PA and VO<sub>2max</sub> can alleviate chronic inflammation, and visfatin plays a positive mediating role.</p>\",\"PeriodicalId\":11116,\"journal\":{\"name\":\"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy\",\"volume\":\"17 \",\"pages\":\"4489-4500\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-11-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607996/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/DMSO.S473266\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/DMSO.S473266","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Effects of Physical Activity, VO2max, and Visfatin on Relationship Between BMI and Chronic Inflammation.
Purpose: This study aims to explore the relationship between BMI and chronic inflammation and to investigate the interaction and mediation of physical activity (PA), cardiopulmonary function, and visfatin.
Methods: A total of 119 participants were included in the study, 60 in the obesity group, 30 in the normal weight group, and 29 in the overweight group. PA, VO2max, visfatin, high-sensitivity C-reactive protein (hs-CRP), and four blood lipid indices (TC, TG, HDLC, LDLC) were analyzed. Regression analysis was used to understand the effect of BMI on chronic inflammation. Covariate analysis was conducted to screen effective covariates affecting BMI to predict chronic inflammation and test the interaction and intermediary role of effective covariates.
Results: The increase in BMI could aggravate chronic inflammation. PA, VO2max, and visfatin had interactive effects on BMI affecting chronic inflammation, and visfatin played an intermediary role in BMI affecting chronic inflammation. The effect value of BMI on chronic inflammation in terms of low PA was 3.5 times higher than that of high PA, that of low VO2max was 2.8 times higher than that of high VO2max, and that of high visfatin was 3.65 times higher than that of low visfatin. Approximately 19.35% of the effect was mediated by visfatin.
Conclusion: An increase in BMI can aggravate chronic inflammation. Increases in PA and VO2max can alleviate chronic inflammation, and visfatin plays a positive mediating role.
期刊介绍：
An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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