Jordan Killingsworth, Rachel Boren, Rachna Sheth, Michael L Chang
{"title":"棘白菌素预防青少年急性髓性白血病感染的研究。","authors":"Jordan Killingsworth, Rachel Boren, Rachna Sheth, Michael L Chang","doi":"10.1155/crdi/4459447","DOIUrl":null,"url":null,"abstract":"<p><p>We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a <i>Saprochaete capitata</i> disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.</p>","PeriodicalId":9608,"journal":{"name":"Case Reports in Infectious Diseases","volume":"2024 ","pages":"4459447"},"PeriodicalIF":1.0000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606694/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Saprochaete capitata</i> Infection in Teen With Acute Myeloid Leukemia Receiving Echinocandin Prophylaxis.\",\"authors\":\"Jordan Killingsworth, Rachel Boren, Rachna Sheth, Michael L Chang\",\"doi\":\"10.1155/crdi/4459447\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a <i>Saprochaete capitata</i> disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.</p>\",\"PeriodicalId\":9608,\"journal\":{\"name\":\"Case Reports in Infectious Diseases\",\"volume\":\"2024 \",\"pages\":\"4459447\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606694/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Case Reports in Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/crdi/4459447\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Case Reports in Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/crdi/4459447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Saprochaete capitata Infection in Teen With Acute Myeloid Leukemia Receiving Echinocandin Prophylaxis.
We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a Saprochaete capitata disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.
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