对酶热稳定性的新见解：“短板”理论和零射击哈密顿模型（Adv. Sci. 45/2024）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2024-12-04 DOI:10.1002/advs.202470274

Min Liao, Shihao Feng, Xiaoqing Liu, Guoshun Xu, Sicong Li, Yingguo Bai, Huiying Luo, Bin Yao, Haobo Wang, Tao Tu

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引用次数: 0

摘要

酶热稳定性的“短板”理论“短板”效应概念表明，针对蛋白质内的关键薄弱区域在确定酶稳定性的上限方面起着至关重要的作用，并具有增强酶热稳定性的巨大潜力。这就好比孙悟空学成归来，金箍棒是他变成孙悟空的核心要素。更多的细节可以在tutao， Haobo Wang及其同事的文章编号2402441中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Novel Insights into Enzymatic Thermostability: The “Short Board” Theory and Zero-Shot Hamiltonian Model (Adv. Sci. 45/2024)

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Novel Insights into Enzymatic Thermostability: The “Short Board” Theory and Zero-Shot Hamiltonian Model (Adv. Sci. 45/2024)

The “Short Board” Theory for Enzymatic Thermostability

The “short board” effect concept suggests that the targeting of critical weak regions within proteins plays a crucial role in determining the upper threshold of enzymatic stability and holds significant potential for enhancing enzyme thermostability. This is analogous to Sun Wukong's return after acquiring knowledge, with the golden cudgel serving as the core factor in his transformation into the Monkey King. More details can be found in article number 2402441 by Tao Tu, Haobo Wang, and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.