携带miR-21-5p的DNA四面体通过协同调节成骨和血管生成促进衰老骨缺陷修复（ad . Healthcare Mater. 30/2024）

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2024-12-04 DOI:10.1002/adhm.202470190

Lei Qi, Shebin Hong, Tong Zhao, Jinge Yan, Weiwen Ge, Jing Wang, Xin Fang, Weidong Jiang, Steve GF Shen, Lei Zhang

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引用次数: 0

摘要

本研究构建了基于DNA四面体的TDN-miR-21-5p纳米复合物，在体外促进O-BMSCs成骨和延缓衰老，同时促进O-EPCs血管生成。此外，TDN-miR-21-5p@GelMA支架可促进体内衰老骨修复，为衰老骨修复提供了一种新的候选策略，拓宽了基于tdns的基因治疗的临床应用。更多细节可以在文章2401275中找到，作者是蒋卫东、Steve GF Shen、张磊及其同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

DNA Tetrahedron Delivering miR-21-5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. Healthcare Mater. 30/2024)

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DNA Tetrahedron Delivering miR-21-5p Promotes Senescent Bone Defects Repair through Synergistic Regulation of Osteogenesis and Angiogenesis (Adv. Healthcare Mater. 30/2024)

Senescent Bone Repair

The work constructed a TDN-miR-21-5p nanocomplex based on DNA tetrahedral that promotes osteogenesis and alleviates senescence of O-BMSCs, simultaneously enhances angiogenesis of O-EPCs in vitro. In addition, TDN-miR-21-5p@GelMA scaffold could promote senescent bone repair in vivo, which provides a novel candidate strategy for senescent bone repair and widen clinical application of TDNs-based gene therapy. More details can be found in article 2401275 by Weidong Jiang, Steve GF Shen, Lei Zhang, and co-workers.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.