双猝灭探针“开启”NIR-II荧光，用于组织蛋白酶B的体内敏感成像

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-11-26 DOI:10.1039/d4cc05784h

Yu Deng , Kui Yan , Lingling Xu , Xiaoyang Liu , Furong Zhao , Shangfeng Wang , Fan Zhang , Gaolin Liang , Rui Wang

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引用次数: 0

摘要

我们设计了一种NIR-II荧光探针，Cys(StBu)-Gly-Phe-Leu-Gly-Lys(AF3)-CBT (AF3-CBT)，形成双猝灭的纳米粒子AF3- np。在CTSB裂解下，NIR-II荧光“开启”，对CTSB进行敏感成像。AF3-NP在体外、细胞内和体内的NIR-II荧光强度分别比对照组高6.1倍、3.2倍和2.1倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

“Turn-on” NIR-II fluorescence of a dually quenched probe for sensitive imaging of cathepsin B in vivo†

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“Turn-on” NIR-II fluorescence of a dually quenched probe for sensitive imaging of cathepsin B in vivo†

We designed a NIR-II fluorescence probe, Cys(StBu)-Gly-Phe-Leu-Gly-Lys(AF3)-CBT (AF3-CBT), which forms a dually quenched nanoparticle AF3-NP. Under CTSB cleavage, NIR-II fluorescence turns “On” for sensitive imaging of CTSB. AF3-NP showed 6.1-fold, 3.2-fold, and 2.1-fold higher NIR-II fluorescence intensities compared to those of the control group in vitro, in cells, and in vivo, respectively.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.