来自不同亚洲献血者的血细胞类型的选择性剪接的遗传控制

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-12-04 DOI:10.1038/s41588-024-02020-1

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引用次数: 0

摘要

现有的功能基因组数据集以欧洲为中心。亚洲免疫多样性图谱结合了来自大约500名不同亚洲血统捐献者的大约100万个外周血单个核细胞的单细胞rna测序数据。剪接数量性状位点的定位揭示了选择性剪接的环境特异性调控，以及细胞类型和祖先特异性遗传对复杂疾病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Genetic control of alternative splicing across blood cell types from diverse Asian donors

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Genetic control of alternative splicing across blood cell types from diverse Asian donors

Existing functional genomics datasets are European-centric. The Asian Immune Diversity Atlas incorporated single-cell RNA-sequencing data from approximately 1 million peripheral blood mononuclear cells from around 500 donors of diverse Asian ancestries. Mapping of splicing quantitative trait loci revealed context-specific regulation of alternative splicing, as well as cell-type and ancestry-specific genetic effects on complex diseases.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution