无溶剂条件下芳基甲基胺与芳基甲基酮持续N-α-C(sp3)-H功能化合成Kröhnke吡啶

IF 2.3 4区化学 Q3 CHEMISTRY, PHYSICAL

Catalysis Letters Pub Date : 2024-12-02 DOI:10.1007/s10562-024-04873-x

Vikas D. Kadu, Sankala Naga Chandrudu, Mahesh G. Hublikar, Shahaji I. Bansode, Raghunath B. Bhosale

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引用次数: 0

摘要

提出了一种用N-α-C(sp3)-H直接功能化芳基甲胺合成取代2,4,6-三芳基吡啶的高效“一锅法”。令人着迷的是，这种方法的特点是O2作为氧化剂，无金属的简单反应操作和芳基甲胺的双重作用。易得的简单甲胺的自氧化偶联，以及它们与芳基甲基酮的顺序脱胺/环化级联，已经完成了预期的2,4,6-三芳基吡啶（20个例子），产率高达95%，具有良好的官能团耐受性。在氧化剂O2存在下的直接反应条件和生成的唯一副产物H2O使该过程对环境友好。图形抽象

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Metal-Free Sustainable N-α-C(sp3)-H Functionalization of Arylmethylamines with Arylmethylketones to Synthesis of Kröhnke Pyridines Under Solvent-free Condition

An efficient “one pot” direct N-α-C(sp³)-H functionalization of arylmethylamines towards synthesis of substituted 2,4,6-triarylpyridines has developed. Fascinatingly, this method features O₂ as an oxidant, metal-free simple reaction operation and the dual role of arylmethylamines. The self-oxidative coupling of readily available simple methylamines followed by their sequential deamination/cyclization cascade with arylmethylketones has accomplished anticipated 2,4,6-triarylpyridines (20 examples) up to 95% yield with good functional groups tolerance. The straightforward reaction condition in the presence of an oxidant O₂ and generated H₂O as a sole byproduct made this process environmentally friendly.

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来源期刊

Catalysis Letters 化学-物理化学

CiteScore

5.70

自引率

3.60%

发文量

327

审稿时长

1 months

期刊介绍： Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis. The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.