有机汞寡核苷酸-聚多巴胺纳米粒子组件通过Hg（ii）介导的碱基配对†区分目标序列

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2024-12-03 DOI:10.1039/D4RA07922A

Tharun K. Kotammagari, Majid Al-Waeel, Jukka Lukkari and Tuomas Lönnberg

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引用次数: 0

摘要

合成了含有单个5-汞胞嘧啶残基的荧光标记寡核苷酸杂交探针，并发现其对聚多巴胺纳米粒子的吸附比其非金属对偶物强得多。与靶序列杂交导致探针从纳米颗粒中不同程度地释放，这取决于与5-汞胞嘧啶相反的核碱基。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Organomercury oligonucleotide–polydopamine nanoparticle assemblies discriminate between target sequences by Hg(ii)-mediated base pairing†

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Organomercury oligonucleotide–polydopamine nanoparticle assemblies discriminate between target sequences by Hg(ii)-mediated base pairing†

A fluorescently tagged oligonucleotide hybridization probe incorporating a single 5-mercuricytosine residue was synthesized and found to adsorb on polydopamine nanoparticles much more strongly than its unmetallated counterpart. Hybridization with target sequences led to release of the probe from the nanoparticle to varying degrees depending on the nucleobase opposite to 5-mercuricytosine.

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来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.