ITGA5+滑膜成纤维细胞亚群改变类风湿关节炎的炎症生态位

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2024-12-03 DOI:10.1038/s41584-024-01197-3

Holly Webster

引用次数: 0

摘要

ITGA5+滑膜成纤维细胞亚群释放TGFβ可促进RA中致病性PD-1hiCXCL13+ T细胞的分化，改变炎症生态位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A subset of ITGA5+ synovial fibroblasts alter the inflammatory niche in RA

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A subset of ITGA5+ synovial fibroblasts alter the inflammatory niche in RA

The release of TGFβ by a subset of ITGA5+ synovial fibroblasts can promote the differentiation of pathogenic PD-1hiCXCL13+ T cells in RA, altering the inflammatory niche.

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.