Afeng Hou, Zhenmei Lin, Yongfang Cheng, Yaoping Tang, Qing Chen, Lingfeng Jiang, Li Li and Ziqian Zhang
{"title":"利用荧光实时监测一氧化氮和硫化氢的光触发双气体供体释放","authors":"Afeng Hou, Zhenmei Lin, Yongfang Cheng, Yaoping Tang, Qing Chen, Lingfeng Jiang, Li Li and Ziqian Zhang","doi":"10.1039/D4AN01156B","DOIUrl":null,"url":null,"abstract":"<p >Multi-gaseous signal molecules play a significant role in regulating various physiological and pathological processes. Therefore, studying the synergistic effects of multi-gas donors on biological systems is essential. However, different types of gas donors vary significantly in terms of gas release, including location, dose, and flux. These variations can have a dramatic impact on the biological effects of the gases and require further analysis for confirmation. Thus, a controllable dual-gas donor that enables self-reporting would be valuable for studying the biological effects of two species of gaseous signal molecules. Herein, we present a novel photo-triggered donor, <strong>NHD545</strong>, which releases nitric oxide and hydrogen sulfide simultaneously. Furthermore, the dual-gas release from this donor is accompanied by turn-on fluorescence, which could be utilized to monitor the NO and H<small><sub>2</sub></small>S release by microscopy. With <strong>NHD545</strong>, it is convenient to investigate the synergistic effect of dual-gas bioavailability <em>in vitro</em>.</p>","PeriodicalId":63,"journal":{"name":"Analyst","volume":" 2","pages":" 378-385"},"PeriodicalIF":3.6000,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A photo-triggered dual-gas donor of nitric oxide and hydrogen sulfide with fluorescence for real-time monitoring of its release†\",\"authors\":\"Afeng Hou, Zhenmei Lin, Yongfang Cheng, Yaoping Tang, Qing Chen, Lingfeng Jiang, Li Li and Ziqian Zhang\",\"doi\":\"10.1039/D4AN01156B\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Multi-gaseous signal molecules play a significant role in regulating various physiological and pathological processes. Therefore, studying the synergistic effects of multi-gas donors on biological systems is essential. However, different types of gas donors vary significantly in terms of gas release, including location, dose, and flux. These variations can have a dramatic impact on the biological effects of the gases and require further analysis for confirmation. Thus, a controllable dual-gas donor that enables self-reporting would be valuable for studying the biological effects of two species of gaseous signal molecules. Herein, we present a novel photo-triggered donor, <strong>NHD545</strong>, which releases nitric oxide and hydrogen sulfide simultaneously. Furthermore, the dual-gas release from this donor is accompanied by turn-on fluorescence, which could be utilized to monitor the NO and H<small><sub>2</sub></small>S release by microscopy. With <strong>NHD545</strong>, it is convenient to investigate the synergistic effect of dual-gas bioavailability <em>in vitro</em>.</p>\",\"PeriodicalId\":63,\"journal\":{\"name\":\"Analyst\",\"volume\":\" 2\",\"pages\":\" 378-385\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-12-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analyst\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/an/d4an01156b\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analyst","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/an/d4an01156b","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
A photo-triggered dual-gas donor of nitric oxide and hydrogen sulfide with fluorescence for real-time monitoring of its release†
Multi-gaseous signal molecules play a significant role in regulating various physiological and pathological processes. Therefore, studying the synergistic effects of multi-gas donors on biological systems is essential. However, different types of gas donors vary significantly in terms of gas release, including location, dose, and flux. These variations can have a dramatic impact on the biological effects of the gases and require further analysis for confirmation. Thus, a controllable dual-gas donor that enables self-reporting would be valuable for studying the biological effects of two species of gaseous signal molecules. Herein, we present a novel photo-triggered donor, NHD545, which releases nitric oxide and hydrogen sulfide simultaneously. Furthermore, the dual-gas release from this donor is accompanied by turn-on fluorescence, which could be utilized to monitor the NO and H2S release by microscopy. With NHD545, it is convenient to investigate the synergistic effect of dual-gas bioavailability in vitro.
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