DMSO-K2S2O8介导的糖基C-3醚无碘转化为3-烯吡喃酮:呋喃[3,2-c]吡喃的合成

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Bisma Rasool , Sanchari Kundu , Irshad Ahmad Zargar , Debaraj Mukherjee
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引用次数: 0

摘要

采用DMSO-K2S2O8试剂体系,建立了一种直接将3- o -苄基化和硅基化甘醛转化为相应烯酮的简单、高效和区域选择性的方法。该反应在温和条件下可扩展到克数,收率可达80%。所得到的烯酮是合成呋喃[3,2-c]吡喃的有价值的中间体,呋喃是各种具有重要生物学意义的支架的组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

DMSO–K2S2O8 mediated iodine-free conversion of glycal C-3 ether to 3-enopyranones: synthesis of furo[3,2-c] pyrans†

DMSO–K2S2O8 mediated iodine-free conversion of glycal C-3 ether to 3-enopyranones: synthesis of furo[3,2-c] pyrans†

DMSO–K2S2O8 mediated iodine-free conversion of glycal C-3 ether to 3-enopyranones: synthesis of furo[3,2-c] pyrans†
A straightforward, highly efficient, and regioselective method for directly converting 3-O-benzylated and silylated glycals into their corresponding enones has been developed using a DMSO–K2S2O8 reagent system. This reaction is scalable to gram quantities under mild conditions, achieving up to 80% yields. The resulting enones are valuable intermediates for the synthesis of furo[3,2-c] pyrans, which are integral components of various biologically significant scaffolds.
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍: ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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