Zohreh Dalirsani, Maryam Amirchaghmaghi, Mahshid Malakuti Semnani, Mahdi Talebi, Seyed Isaac Hashemy, Mohammad Taghi Shakeri, Ava Taghizadeh
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In addition, opiorphin concentration in BMS patients before and after psychiatric treatment was compared and the association between burning severity and psychiatric scores with salivary opiorphin concentration was examined.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>This cross-sectional study included 28 BMS patients and 40 healthy individuals referred to the Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Mashhad, from September 2018 to August 2019. Patients with proven disease based on clinical and psychiatric examinations were included in the study. Unstimulated salivary opiorphin levels were assessed by ELISA. Statistical analysis was performed using SPSS version 24.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Salivary opiorphin levels were significantly higher in BMS patients (2.16 ± 0.30 ng/mL) than in healthy subjects (1.80 ± 0.36 ng/mL) (<i>p</i> < 0.001). Opiorphin levels in BMS patients increased insignificantly after psychiatric therapy (<i>p</i> = 0.212). In addition, there was no significant association between opiorphin levels and age, gender, menopause, burning severity, anxiety, and depression status.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The opiorphin concentration in saliva is higher in BMS patients than in healthy subjects. Most BMS patients also suffer from anxiety and depression.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"10 6","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.934","citationCount":"0","resultStr":"{\"title\":\"Comparison of Salivary Opiorphin in Burning Mouth Syndrome and Healthy Subjects and Its Correlation With Psychiatric Disorders\",\"authors\":\"Zohreh Dalirsani, Maryam Amirchaghmaghi, Mahshid Malakuti Semnani, Mahdi Talebi, Seyed Isaac Hashemy, Mohammad Taghi Shakeri, Ava Taghizadeh\",\"doi\":\"10.1002/cre2.934\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Burning mouth syndrome (BMS) is a chronic disease in which the patient experiences a burning sensation in the oral mucosa without any pathological cause. Opiorphin is a pentapeptide that prevents pain and can have an antidepressant effect. The aim of this study was to evaluate salivary opiorphin concentration in BMS and healthy subjects. In addition, opiorphin concentration in BMS patients before and after psychiatric treatment was compared and the association between burning severity and psychiatric scores with salivary opiorphin concentration was examined.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Materials and Methods</h3>\\n \\n <p>This cross-sectional study included 28 BMS patients and 40 healthy individuals referred to the Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Mashhad, from September 2018 to August 2019. Patients with proven disease based on clinical and psychiatric examinations were included in the study. Unstimulated salivary opiorphin levels were assessed by ELISA. Statistical analysis was performed using SPSS version 24.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Salivary opiorphin levels were significantly higher in BMS patients (2.16 ± 0.30 ng/mL) than in healthy subjects (1.80 ± 0.36 ng/mL) (<i>p</i> < 0.001). Opiorphin levels in BMS patients increased insignificantly after psychiatric therapy (<i>p</i> = 0.212). In addition, there was no significant association between opiorphin levels and age, gender, menopause, burning severity, anxiety, and depression status.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The opiorphin concentration in saliva is higher in BMS patients than in healthy subjects. 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引用次数: 0
摘要
灼口综合征（BMS）是一种慢性疾病，患者无任何病理原因，口腔黏膜有烧灼感。Opiorphin是一种五肽，可以防止疼痛，并具有抗抑郁作用。本研究的目的是评估BMS和健康受试者唾液中opiorphin的浓度。此外，我们还比较了BMS患者在精神治疗前后的opiorphin浓度，并检测了灼烧严重程度和精神病学评分与唾液opiorphin浓度的关系。材料与方法本横断面研究包括2018年9月至2019年8月在马什哈德牙科学院口腔颌面医学系就诊的28例BMS患者和40名健康个体。经临床和精神病学检查证实患病的患者被纳入研究。ELISA法检测非刺激唾液opiorphin水平。采用SPSS version 24进行统计分析。结果BMS患者唾液opiorphin水平（2.16±0.30 ng/mL）显著高于健康对照组（1.80±0.36 ng/mL） （p < 0.001）。精神治疗后BMS患者的Opiorphin水平无明显升高（p = 0.212）。此外，opiorphin水平与年龄、性别、更年期、烧伤严重程度、焦虑和抑郁状态之间无显著相关性。结论BMS患者唾液中opiorphin浓度高于健康人群。大多数BMS患者还患有焦虑和抑郁。
Comparison of Salivary Opiorphin in Burning Mouth Syndrome and Healthy Subjects and Its Correlation With Psychiatric Disorders
Objectives
Burning mouth syndrome (BMS) is a chronic disease in which the patient experiences a burning sensation in the oral mucosa without any pathological cause. Opiorphin is a pentapeptide that prevents pain and can have an antidepressant effect. The aim of this study was to evaluate salivary opiorphin concentration in BMS and healthy subjects. In addition, opiorphin concentration in BMS patients before and after psychiatric treatment was compared and the association between burning severity and psychiatric scores with salivary opiorphin concentration was examined.
Materials and Methods
This cross-sectional study included 28 BMS patients and 40 healthy individuals referred to the Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Mashhad, from September 2018 to August 2019. Patients with proven disease based on clinical and psychiatric examinations were included in the study. Unstimulated salivary opiorphin levels were assessed by ELISA. Statistical analysis was performed using SPSS version 24.
Results
Salivary opiorphin levels were significantly higher in BMS patients (2.16 ± 0.30 ng/mL) than in healthy subjects (1.80 ± 0.36 ng/mL) (p < 0.001). Opiorphin levels in BMS patients increased insignificantly after psychiatric therapy (p = 0.212). In addition, there was no significant association between opiorphin levels and age, gender, menopause, burning severity, anxiety, and depression status.
Conclusions
The opiorphin concentration in saliva is higher in BMS patients than in healthy subjects. Most BMS patients also suffer from anxiety and depression.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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