LMO2对泛癌组织中CD8+ t淋巴细胞浸润的指示作用分析

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2024-12-01 DOI:10.1016/j.bbrep.2024.101890

Yanhong Yu , Mei Yuan , Zhao Zhang , Dan Wang , Wei Sun

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引用次数: 0

摘要

LMO2是造血的关键因子，在各种上皮细胞和实体肿瘤中也广泛表达，研究表明，在一些肿瘤细胞中，LMO2水平升高可促进肿瘤微环境中CD8+ t淋巴细胞的浸润。在此，我们扩大了这种效应在泛癌谱中的研究，转录组数据分析显示LMO2与泛癌中CD8+ t淋巴细胞浸润之间存在广泛的正相关。同时，组织染色显示LMO2在不同组织及肿瘤组织中的表达水平不同，且具有一致的胞质定位，进一步表明LMO2在恶性细胞中的高表达与CD8+ t淋巴细胞选择性浸润在消化道、乳腺和肾脏肿瘤中密切相关。综上所述，本研究全面描绘了LMO2在泛癌症中与肿瘤免疫学的功能联系，并为LMO2在肿瘤免疫治疗领域的意义提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Analysis of the effect of LMO2 on indicating CD8+ T-lymphocyte infiltration in pan-cancers

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Analysis of the effect of LMO2 on indicating CD8+ T-lymphocyte infiltration in pan-cancers

LMO2 is a critical factor in hematopoiesis but widely expressed in kinds of epithelia and solid tumors as well, and it has been demonstrated that increased LMO2 level in some tumor cells exhibits an effect on promoting CD8⁺ T-lymphocyte infiltration in tumor microenvironment. Herein we expanded the investigation of such effect in pan-cancer spectrum, and the transcriptome data analysis revealed extensively positive associations between LMO2 and CD8⁺ T-lymphocyte infiltration in pan-cancers. Meanwhile, tissue staining revealed variable expression level and consistently cytosolic localization of LMO2 in different tissues and their tumor counterparts, and further indicated that high LMO2 expression in malignant cells was strongly associated with positive CD8⁺ T-lymphocyte infiltration selectively in digestive tract, breast and kidney tumors. Taken together, this study depicted an overall view of LMO2 functional linkage with tumor immunology in pan-cancers and provided novel insight of LMO2 significance in the field of tumor immune therapy.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.