水溶性姜黄素-壳寡糖配合物的制备、表征及抗菌研究

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2024-11-29 DOI:10.1016/j.carbpol.2024.123083

Xingchen Zhai , Yu Guo , Man Shang , Ziyan Guo , Difeng Ren , A.M. Abd El-Aty

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引用次数: 0

摘要

姜黄素具有广泛的应用前景，在食品工业和生物医学领域具有多种生物活性。但姜黄素水溶性差，对pH、光和温度敏感。本研究采用机械化学方法制备了姜黄素-壳寡糖（curin -chitooligosaccharide, CUR-COS）配合物，该配合物冻干后的可溶性比姜黄素高862倍。通过SEM、XRD、FT-IR和热分析对配合物进行了表征，并评价了配合物对pH、光照和热处理的稳定性。大豆可作为姜黄素的载体。此外，还测定了所形成的配合物的抗菌活性。结果表明，与纯CUR相比，CUR- cos具有更好的水溶性、更强的稳定性和更强的抗菌性能，为亲脂性天然产物在食品特别是水基产品中的广泛应用提供了一条有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes

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Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes

Curcumin has a wide range of application prospects, with various bioactivities in the food industry and in the biomedical field. However, curcumin has poor water solubility and is sensitive to pH, light and temperature. In this study, curcumin-chitooligosaccharide (CUR-COS) complexes were prepared via mechanochemical methods, and the CUR-COS complex was more soluble after freeze-drying (up to 862-fold greater than that of curcumin). The complex was characterized by SEM, XRD, FT-IR and thermal analysis, and its stability against pH, light and thermal treatment was evaluated. COSs could serve as carriers for curcumin delivery. Additionally, the antibacterial activity of the formed complex was determined. As a result, CUR-COS exhibited significantly better water solubility, enhanced stability, and stronger antibacterial properties than did pure CUR, offering a promising pathway for the extensive application of lipophilic natural products in foods, especially water-based products.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.