液滴数字PCR技术在传染病病原体诊断领域应用的全球趋势：2012 - 2023年文献计量学分析

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-11-26 DOI:10.1016/j.diagmicrobio.2024.116623

Xiaojie Yang , Fengting Yu , Chang Yan , Mengying Li , Xuelei Liang , Xiaojie Lao , Rui Sun , Wenhao Lv , Hanxi Zhang , Fujie Zhang

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引用次数: 0

摘要

本文综述了数字液滴PCR技术在病原体诊断中的发展趋势和应用现状。方法检索Web of Science Core Collection中2012年1月1日至2023年12月31日发表的液滴数字pcr相关文章，进行文献计量学分析。结果共有来自66个国家的3513位作者在203个学术机构发表了508篇研究论文。关键词聚类网络表明，ddPCR的主要优势是绝对定量、高灵敏度和对PCR抑制剂的高耐受性。关键词时间轴显示，当前的研究热点包括病原核酸连续监测、微量样本检测、抗性突变鉴定等。结论ddPCR在病原体诊断中的应用日益扩大，具有绝对定量、高灵敏度和抑制剂耐受性等优势，满足了核酸监测和耐药性检测的新需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Global trends in the application of droplet digital PCR technology in the field of infectious disease pathogen diagnosis: A bibliometric analysis from 2012 to 2023

Background

This study discusses the development trends and current applications of digital droplet PCR technology in pathogen diagnostics.

Methods

A bibliometric analysis was conducted by retrieving droplet digital pcr related articles published between January 1,2012 to December31, 2023, from the Web of Science Core Collection.

Results

A total of 3,513 authors from 66 countries published 508 research papers across 203 academic institutions. The keyword clustering network shows that the main advantages of ddPCR are absolute quantification, high sensitivity, and high tolerance to PCR inhibitors. The keyword timeline shows that current research hotspots include continuous pathogen nucleic acid monitoring, trace sample detection, and resistance mutation identification.

Conclusion

The application of ddPCR in pathogen diagnosis is expanding, offering key advantages in absolute quantification, high sensitivity, and inhibitor tolerance, meeting emerging needs in nucleic acid monitoring and resistance detection.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.