包含单细胞转录组和TCR信息的人CD8+ T细胞图谱。

IF 36.1 1区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Nature Methods Pub Date : 2024-11-29 DOI:10.1038/s41592-024-02529-7

引用次数: 0

摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Human CD8+ T cell map with single-cell transcriptome and TCR information

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Human CD8+ T cell map with single-cell transcriptome and TCR information

We developed scAtlasVAE, a deep-learning-based method to integrate large-scale single-cell RNA sequencing data. Using this tool, we established a comprehensive, million-scale, pan-disease human CD8+ T cell reference atlas, which incorporates information on transcriptomes and the diversity of the αβ T cell receptor repertoire.

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来源期刊

Nature Methods 生物-生化研究方法

CiteScore

58.70

自引率

1.70%

发文量

326

审稿时长

1 months

期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.