乳腺癌循环肿瘤细胞：临床有效性和实用性。

IF 6.5 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2024-11-29 DOI:10.1038/s41523-024-00706-7

Thibault Thomas-Bonafos, Jean Yves Pierga, François-Clément Bidard, Luc Cabel, Nicolas Kiavue

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引用次数: 0

摘要

循环肿瘤细胞（CTCs）在乳腺癌（BC）中得到了广泛的研究，大量研究证实CTCs是早期和转移性乳腺癌（MBC）的预后生物标志物。一些II期和III期试验研究了ctc在BC中的临床应用。在这里，我们概述了目前在BC不同阶段的临床中使用ctc的情况，首先关注早期BC，然后是MBC，特别关注基于ctc的介入性临床试验。

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Circulating tumor cells in breast cancer: clinical validity and utility.

Circulating tumor cells (CTCs) have been extensively studied in breast cancer (BC), with large studies establishing CTCs as a robust prognostic biomarker in early and metastatic breast cancer (MBC). Several phase II and phase III trials have investigated the clinical utility of CTCs in BC. Here, we outline the current landscape for the use of CTCs in the clinic at different stages of BC, focusing first on early BC, then on MBC, with a particular focus on interventional clinical trials based on CTCs.

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.