Skull base osteomyelitis: HBO as a therapeutic concept Effects on clinical and radiological results.

Introduction: Skull base osteomyelitis is a rare but potentially life-threatening disease. It usually occurs as a complication of severe otitis externa or infection in the nasopharynx, often in immunocompromised patients. The therapeutic strategy is complex, patient-specific and requires interdisciplinary cooperation.

Material and method: A retrospective evaluation of all patients with skull base osteomyelitis at the Department of Otorhinolaryngology of the University Hospital Duesseldorf from 2006 to 2023 was carried out. It was investigated which factors, in addition to treatment regimens (antibiotic therapy with i.v./oral antibiotics, surgical debridement and HBO therapy) have an influence on the clinical, laboratory and morphological outcome of the patients.

Results: A total of 42 patients who received interdisciplinary treatment in our clinic were included in the study, of whom 71.4% were male and 28.6% female. The tissue samples showed an inflammatory process, with detection of Pseudomonas aeruginosa in 68.4% of patients. A total of 61.9% of patients presented cranial nerve deficits, most frequently facial nerve palsy. A total of 66.7% of patients received HBO therapy. Of these, n = 20/23 patients (87%) with HBO improved and achieved regression in the follow-up imaging. Known patient-specific factors were confirmed and HBO was emphasized as an important component of the multimodal therapy concept. HBO appears to be justified and should continue to be included in the treatment regimen in the future. For this reason, patients with SBO should be sent to a center that offers HBO therapy.