光诱导芳构化驱动的螺旋二氢喹唑啉酮的解构氟磺化

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-11-30 DOI:10.1021/acs.joc.4c02304

Wen-Peng Yang, Hong-Jie Miao, Gang Wang, Xiaoyu Yang, Xianjun Wang, Le Liu, Xin-Hua Duan, Li-Na Guo

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引用次数: 0

摘要

报道了一种无催化剂光诱导双氢喹唑啉酮与DABSO和NFSI的解构氟磺化级联反应。该工艺具有反应条件温和、产率高、官能团耐受性好等特点，为喹唑啉-4(1H)- 1功能化脂肪磺酰氟化合物的制备提供了一条实用途径。此外，克级合成的便利性和SuFEx交换的多功能性突出了该协议的应用潜力。

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Photoinduced Aromatization-Driven Deconstructive Fluorosulfonylation of Spiro Dihydroquinazolinones

A catalyst-free photoinduced deconstructive fluorosulfonylation cascade of spiro dihydroquinazolinones with DABSO and NFSI is reported. This protocol features mild reaction conditions, good yields and excellent functional group tolerance, providing a practical approach to the quinazolin-4(1H)-one-functionalized aliphatic sulfonyl fluorides. In addition, the ease of gram-scale synthesis and the versatility of the SuFEx exchange highlight the application potential of this protocol.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.