微波消融治疗伴有美容问题的良性甲状腺结节及其消融后完全缓解的相关因素：一项双中心回顾性研究。

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2025-03-01 Epub Date: 2024-11-28 DOI:10.1007/s12020-024-04103-9

Xiao-Long Li, Zi-Tong Chen, Yun-Jie Jin, Ben-Hua Xu, Ya-Dan Xu, Qiong Cao, Xiao-Wan Bo, Jie-Xian Wen, Zheng-Biao Ji, Pei-Li Fan, Hui-Xiong Xu

{"title":"微波消融治疗伴有美容问题的良性甲状腺结节及其消融后完全缓解的相关因素：一项双中心回顾性研究。","authors":"Xiao-Long Li, Zi-Tong Chen, Yun-Jie Jin, Ben-Hua Xu, Ya-Dan Xu, Qiong Cao, Xiao-Wan Bo, Jie-Xian Wen, Zheng-Biao Ji, Pei-Li Fan, Hui-Xiong Xu","doi":"10.1007/s12020-024-04103-9","DOIUrl":null,"url":null,"abstract":"Purpose: To investigate the efficacy of ultrasound (US)-guided percutaneous MWA for benign thyroid nodules with cosmetic problems and identify related factors contributing to post-ablative complete relief (CR).Methods: This retrospective study reviewed the efficacy of MWA in treating thyroid nodules in patients with cosmetic problems who underwent MWA from January 2021 to May 2023. Patients were followed up at 1, 3, and 6 months after MWA. Pre-treatment clinical characteristics, conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) features were analyzed to explore their correlation with cosmetic improvement, defined as a cosmetic score of 1 or 2 at the 6-month follow-up. Univariable and multivariable regression analyses were carried out to identify variables associated with CR, and the related nomogram was established. Calibration curve and decision curve analysis were used to evaluate the nomogram performance.Results: 118 patients with 118 nodules were included in the study. During the 1-, 3- and 6-month follow-up, the mean volume reduction ratios (VRR) were 2%, 36% and 73%, respectively. 22.0% (26/118), 57.6% (68/118), and 89.8% (106/118) patients achieved CR of cosmetic problems at 1, 3, and 6 months after MWA. In multivariable analysis, three variables (i.e., non-hashimoto's thyroiditis [HT] [OR: 90.036, P = 0.001], nodule location not close to danger triangle area [OR: 66.812, P = 0.003], early hyperenhancement on CEUS [OR: 0.035, P = 0.024]) were found to be closely associated with CR of cosmetic problems at 6 months after MWA. A nomogram model was constructed, and its accuracy was well validated (i.e., C-index = 0.914).Conclusion: MWA was effective and safe for treating benign thyroid nodules with cosmetic problems. Non-HT, nodule location not close to danger triangle area, and early hyperenhancement on CEUS were associated with CR of cosmetic problems after MWA.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"1080-1089"},"PeriodicalIF":3.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microwave ablation for benign thyroid nodules with cosmetic problems and related factors for post-ablative complete relief: a two-center retrospective study.\",\"authors\":\"Xiao-Long Li, Zi-Tong Chen, Yun-Jie Jin, Ben-Hua Xu, Ya-Dan Xu, Qiong Cao, Xiao-Wan Bo, Jie-Xian Wen, Zheng-Biao Ji, Pei-Li Fan, Hui-Xiong Xu\",\"doi\":\"10.1007/s12020-024-04103-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: To investigate the efficacy of ultrasound (US)-guided percutaneous MWA for benign thyroid nodules with cosmetic problems and identify related factors contributing to post-ablative complete relief (CR).Methods: This retrospective study reviewed the efficacy of MWA in treating thyroid nodules in patients with cosmetic problems who underwent MWA from January 2021 to May 2023. Patients were followed up at 1, 3, and 6 months after MWA. Pre-treatment clinical characteristics, conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) features were analyzed to explore their correlation with cosmetic improvement, defined as a cosmetic score of 1 or 2 at the 6-month follow-up. Univariable and multivariable regression analyses were carried out to identify variables associated with CR, and the related nomogram was established. Calibration curve and decision curve analysis were used to evaluate the nomogram performance.Results: 118 patients with 118 nodules were included in the study. During the 1-, 3- and 6-month follow-up, the mean volume reduction ratios (VRR) were 2%, 36% and 73%, respectively. 22.0% (26/118), 57.6% (68/118), and 89.8% (106/118) patients achieved CR of cosmetic problems at 1, 3, and 6 months after MWA. In multivariable analysis, three variables (i.e., non-hashimoto's thyroiditis [HT] [OR: 90.036, P = 0.001], nodule location not close to danger triangle area [OR: 66.812, P = 0.003], early hyperenhancement on CEUS [OR: 0.035, P = 0.024]) were found to be closely associated with CR of cosmetic problems at 6 months after MWA. A nomogram model was constructed, and its accuracy was well validated (i.e., C-index = 0.914).Conclusion: MWA was effective and safe for treating benign thyroid nodules with cosmetic problems. Non-HT, nodule location not close to danger triangle area, and early hyperenhancement on CEUS were associated with CR of cosmetic problems after MWA.\",\"PeriodicalId\":49211,\"journal\":{\"name\":\"Endocrine\",\"volume\":\" \",\"pages\":\"1080-1089\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12020-024-04103-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-024-04103-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

目的：探讨超声引导下经皮MWA治疗伴有美容问题的良性甲状腺结节的疗效，并探讨影响消融后完全缓解（CR）的相关因素。方法：本回顾性研究回顾了2021年1月至2023年5月MWA治疗美容问题患者甲状腺结节的疗效。术后1、3、6个月对患者进行随访。分析治疗前临床特征、常规超声（US）和造影增强超声（CEUS）特征，探讨其与美容改善的相关性，随访6个月美容评分为1或2分。进行单变量和多变量回归分析，识别与CR相关的变量，并建立相关的模态图。采用标定曲线分析和决策曲线分析对该方法的nomogram性能进行评价。结果：118例患者118个结节纳入研究。在1个月、3个月和6个月的随访中，平均体积缩小率（VRR）分别为2%、36%和73%。22.0%（26/118）、57.6%（68/118）和89.8%（106/118）的患者在MWA后1、3和6个月达到了美容问题的完全缓解。在多变量分析中，三个变量（非桥本甲状腺炎[HT] [OR: 90.036, P = 0.001]，结节位置不靠近危险三角区[OR: 66.812, P = 0.003]，超声造影早期高增强[OR: 0.035, P = 0.024]）与MWA术后6个月美容问题的CR密切相关。构建了nomogram模型，其准确性得到了很好的验证（C-index = 0.914）。结论：MWA治疗伴有美容问题的甲状腺良性结节安全有效。非ht、结节位置不靠近危险三角区、超声造影早期高增强与MWA术后美容问题的CR相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Microwave ablation for benign thyroid nodules with cosmetic problems and related factors for post-ablative complete relief: a two-center retrospective study.

Purpose: To investigate the efficacy of ultrasound (US)-guided percutaneous MWA for benign thyroid nodules with cosmetic problems and identify related factors contributing to post-ablative complete relief (CR).

Methods: This retrospective study reviewed the efficacy of MWA in treating thyroid nodules in patients with cosmetic problems who underwent MWA from January 2021 to May 2023. Patients were followed up at 1, 3, and 6 months after MWA. Pre-treatment clinical characteristics, conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) features were analyzed to explore their correlation with cosmetic improvement, defined as a cosmetic score of 1 or 2 at the 6-month follow-up. Univariable and multivariable regression analyses were carried out to identify variables associated with CR, and the related nomogram was established. Calibration curve and decision curve analysis were used to evaluate the nomogram performance.

Results: 118 patients with 118 nodules were included in the study. During the 1-, 3- and 6-month follow-up, the mean volume reduction ratios (VRR) were 2%, 36% and 73%, respectively. 22.0% (26/118), 57.6% (68/118), and 89.8% (106/118) patients achieved CR of cosmetic problems at 1, 3, and 6 months after MWA. In multivariable analysis, three variables (i.e., non-hashimoto's thyroiditis [HT] [OR: 90.036, P = 0.001], nodule location not close to danger triangle area [OR: 66.812, P = 0.003], early hyperenhancement on CEUS [OR: 0.035, P = 0.024]) were found to be closely associated with CR of cosmetic problems at 6 months after MWA. A nomogram model was constructed, and its accuracy was well validated (i.e., C-index = 0.914).

Conclusion: MWA was effective and safe for treating benign thyroid nodules with cosmetic problems. Non-HT, nodule location not close to danger triangle area, and early hyperenhancement on CEUS were associated with CR of cosmetic problems after MWA.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.