心电图门控视网膜血管口径作为糖尿病患者异常脉冲性视网膜血流的新测量:一项横断面研究。

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes and Metabolic Disorders Pub Date : 2024-09-13 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01439-x
Anchal Lal, Michael Anthony Tony Barry, Paul Mitchell, Aravinda Thiagalingam
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引用次数: 0

摘要

目的:评价心电图门控视网膜血管直径作为糖尿病患者异常脉搏性视网膜血流的新测量方法。方法:采用一种新型心电门控眼底镜,在舒张末期至舒张早期四个心脏周期时间点测量视网膜血管口径。一个内部软件记录了图像被捕获的确切时间,以证实脑电图同步。动脉压扁血压计是一种评估异常血流的替代方法,用于测量颈-股脉波速度(cPWV)和增强指数(AIx)。类内相关(ICC)被用于执行观察者内部和观察者之间的信度分析。两位评论者测量了单个视网膜小动脉和小静脉的视网膜血管直径。受试者工作特征曲线确定与糖尿病的关系。结果:本研究招募了119名对照组和120名糖尿病患者。糖尿病患者视网膜小动脉直径的平均峰值变化高于对照组(对照组:0.92%,IQR为0.63,糖尿病患者为2.05%,IQR为1.25)。结论:视网膜小动脉搏动率升高与糖尿病的相关性明显高于动脉压度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ECG-gated retinal vessel calibre as a novel measure of aberrant pulsatile retinal flow in diabetes mellitus: a cross-sectional study.

Purpose: To evaluate ECG-gated retinal vessel calibre as a novel measure of aberrant pulsatile retinal flow in diabetes mellitus.

Methods: A novel mydriatic ECG-gated fundoscope was used to acquire retinal vessel calibre measurements at four cardiac cycle time points from end diastole to early diastole. An inhouse software recorded the exact time when an image was captured to corroborate ECG-synchronisation. Arterial applanation tonometry, an alternative method of assessing aberrant blood flow, was used to measure carotid-femoral pulse wave velocity (cPWV) and augmentation index (AIx). The intraclass correlation (ICC) was used to perform intra- and inter-observer reliability analyses. Two reviewers measured the retinal vessel calibre in single retinal arterioles and venules. A receiver operating characteristic curve determined associations with diabetes mellitus.

Results: In this study 119 controls and 120 participants with diabetes mellitus were recruited. Mean peak change in retinal arteriolar calibre from baseline was higher in diabetes mellitus compared with controls (controls: 0.92%, IQR 0.63 vs diabetes mellitus: 2.05%, IQR 1.25, p<0.0001). In a subset of 9 controls and 11 participants, the intra-and inter-observer reliability was high (ICC 0.87-0.97) in mean peak changes in retinal vascular responses from baseline. In a subset of 36 controls and 95 participants with diabetes mellitus, diabetes mellitus was more strongly associated with retinal arteriolar pulsatility (AUC 0.85, 95%CI 0.76-0.93) than applanation tonometry (cfPWV AUC 0.72, 95%CI 0.62-0.82 vs AIx AUC 0.56, 95%CI 0.45-0.68).

Conclusion: Higher retinal arteriolar pulsatility appears to be more strongly correlated with diabetes mellitus than arterial applanation tonometry.

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来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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