英国生物银行的生命意义和大脑健康的神经生物标志物。

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI:10.1177/13872877241299053

Angelina Sutin, Martina Luchetti, Yannick Stephan, Antonio Terracciano

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引用次数: 0

摘要

本研究考察了与痴呆风险相关的生命意义和四种神经生物标志物：淀粉样蛋白-β 42比40、磷酸化tau-181、神经丝光和胶质纤维酸性蛋白。无痴呆的成年人(N = 1150；来自英国生物银行（UK Biobank）的研究人员报告了它们在生命中的意义；神经生物标志物检测两次。在两项评估中，生活意义与生物标志物无关（βs范围为-0.03-0.02）。这种关联不受年龄的影响。这些发现不支持没有痴呆症的成年人的生活意义与神经生物标志物相关的假设。意义和认知之间的关系可能是通过其他途径，比如对神经病理学的适应能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Meaning in life and neurobiomarkers of brain health in the UK Biobank.

This study examines meaning in life and four neurobiomarkers implicated in dementia risk: amyloid-β 42 to 40 ratio, phosphorylated tau-181, neurofilament light, and glial fibrillary acidic protein. Adults without dementia (N = 1150; M_age= 59.89) from the UK Biobank reported their meaning in life; neurobiomarkers were assayed twice. Meaning in life was unrelated to the biomarkers at either assessment (βs range -0.03-0.02). No association was moderated by age. These findings do not support the hypothesis that meaning in life is associated with neurobiomarkers in adults without dementia. The relation between meaning and cognition may be through other pathways, such as resilience to neuropathology.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.