线粒体靶向单线态氧传递的喹啉内过氧化物。

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2024-11-29 DOI:10.1002/asia.202401051

Yu Si, Lei Wang, Hao Wu, Shoucai Yan, Yang Wang, Xiao Qian, Ziang Liu, Engin U. Akkaya

{"title":"线粒体靶向单线态氧传递的喹啉内过氧化物。","authors":"Yu Si, Lei Wang, Hao Wu, Shoucai Yan, Yang Wang, Xiao Qian, Ziang Liu, Engin U. Akkaya","doi":"10.1002/asia.202401051","DOIUrl":null,"url":null,"abstract":"<p>Controlled release of singlet oxygen from chemical sources is becoming an interesting path for eliciting apoptotic death of cancer cells. In this work, we present the synthesis and characterization of hitherto unknown class of aromatic endoperoxides, namely quinoline endoperoxides. Quinolines, especially after quaternization, show significant targeting of mitochondria. This leads to more effective cytotoxicity in cancer cell cultures suggesting a potential utility in cancer therapy.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 2","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Quinoline Endoperoxides for Mitochondria Targeted Singlet Oxygen Delivery\",\"authors\":\"Yu Si, Lei Wang, Hao Wu, Shoucai Yan, Yang Wang, Xiao Qian, Ziang Liu, Engin U. Akkaya\",\"doi\":\"10.1002/asia.202401051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Controlled release of singlet oxygen from chemical sources is becoming an interesting path for eliciting apoptotic death of cancer cells. In this work, we present the synthesis and characterization of hitherto unknown class of aromatic endoperoxides, namely quinoline endoperoxides. Quinolines, especially after quaternization, show significant targeting of mitochondria. This leads to more effective cytotoxicity in cancer cell cultures suggesting a potential utility in cancer therapy.</p>\",\"PeriodicalId\":145,\"journal\":{\"name\":\"Chemistry - An Asian Journal\",\"volume\":\"20 2\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry - An Asian Journal\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/asia.202401051\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry - An Asian Journal","FirstCategoryId":"1","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/asia.202401051","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

化学源控制释放单线态氧正成为引发癌细胞凋亡的有趣途径。在这项工作中，我们提出了迄今为止未知的一类芳香过氧化物，即喹啉过氧化物的合成和表征。喹啉类，尤其是季铵化后，对线粒体具有显著的靶向作用。这导致癌细胞培养物中更有效的细胞毒性，表明其在癌症治疗中的潜在效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Quinoline Endoperoxides for Mitochondria Targeted Singlet Oxygen Delivery

Controlled release of singlet oxygen from chemical sources is becoming an interesting path for eliciting apoptotic death of cancer cells. In this work, we present the synthesis and characterization of hitherto unknown class of aromatic endoperoxides, namely quinoline endoperoxides. Quinolines, especially after quaternization, show significant targeting of mitochondria. This leads to more effective cytotoxicity in cancer cell cultures suggesting a potential utility in cancer therapy.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).