An update on adverse health effects from exposure to PM2.5

The impact of fine particulate matter (PM_2.5) on public health has become a global concern due to the mortality and morbidity it entails. Pathophysiological and epidemiological studies have demonstrated an association between PM_2.5 and respiratory diseases, cardiovascular diseases, and neurological disorders. The underlying mechanisms through which PM_2.5 adversely affects human health include the induction of oxidative stress, cytokine release, deoxyribonucleic acid (DNA) damage, altered gene expression, immune toxicity, inflammatory responses, and apoptosis. These outcomes drive the initiation and progression of various diseases. Notably, exposure to PM_2.5 containing chemical compounds may translocate and induce unbalanced intracellular functions at the genetic and epigenetic levels, leading to mutations, carcinogenesis, and multiple diseases. This review aims to summarise and discuss recent updates on the mechanisms linking PM_2.5 exposure to adverse health, highlighting the critical connection between PM_2.5 and health outcomes, with the hope of raising awareness and promoting measures to reduce PM_2.5 levels worldwide.