{"title":"b细胞前体急性淋巴细胞白血病男童新近提出的“斜眼分枝杆菌”导管相关血流感染","authors":"Haruki Naruse , Noriyuki Watanabe , Atsuhiko Ohta , Yuuki Shimizu , Takashi Fukushima , Atsuko Watanabe , Tomohei Nakao , Yoshitada Taji , Yuki Matsumoto , Shota Nakamura , Yuriko Igarashi , Akiko Takaki , Satoshi Mitarai , Kotaro Mitsutake , Ryuhei Tanaka , Yasuhiro Ebihara","doi":"10.1016/j.diagmicrobio.2024.116626","DOIUrl":null,"url":null,"abstract":"<div><div>This report describes a 6-year-old boy who developed non-tuberculosis mycobacteria (NTM) catheter-related bloodstream infection (CRBSI) during treatment for B-cell precursor acute lymphoblastic leukemia. A Hickman catheter was inserted before starting treatment. He developed a fever during chemotherapy, and blood culture was drawn from the catheter. Blurred Gram-positive bacilli were found in Gram stain, looked positive in Ziehl–Neelsen stain, and were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry as <em>Mycobacterium mucogenicum phocaicum</em> group. The administration of clarithromycin and amikacin was started and the Hickman catheter was removed. We performed genomic sequencing to obtain accurate identification, demonstrating that this microorganism was identified as “<em>M. toneyamachuris</em>” calculated by the average nucleotide identity index. Finally, a clinical diagnosis of CRBSI caused by “<em>M. toneyamachuris</em>” was made. Our findings suggest that genomic sequencing is available for the accurate identification of NTM species.</div></div>","PeriodicalId":11329,"journal":{"name":"Diagnostic microbiology and infectious disease","volume":"111 3","pages":"Article 116626"},"PeriodicalIF":2.1000,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Catheter-related bloodstream infection by a newly proposed “Mycobacterium toneyamachuris” in a boy with B-cell precursor acute lymphoblastic leukemia\",\"authors\":\"Haruki Naruse , Noriyuki Watanabe , Atsuhiko Ohta , Yuuki Shimizu , Takashi Fukushima , Atsuko Watanabe , Tomohei Nakao , Yoshitada Taji , Yuki Matsumoto , Shota Nakamura , Yuriko Igarashi , Akiko Takaki , Satoshi Mitarai , Kotaro Mitsutake , Ryuhei Tanaka , Yasuhiro Ebihara\",\"doi\":\"10.1016/j.diagmicrobio.2024.116626\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This report describes a 6-year-old boy who developed non-tuberculosis mycobacteria (NTM) catheter-related bloodstream infection (CRBSI) during treatment for B-cell precursor acute lymphoblastic leukemia. A Hickman catheter was inserted before starting treatment. He developed a fever during chemotherapy, and blood culture was drawn from the catheter. Blurred Gram-positive bacilli were found in Gram stain, looked positive in Ziehl–Neelsen stain, and were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry as <em>Mycobacterium mucogenicum phocaicum</em> group. The administration of clarithromycin and amikacin was started and the Hickman catheter was removed. We performed genomic sequencing to obtain accurate identification, demonstrating that this microorganism was identified as “<em>M. toneyamachuris</em>” calculated by the average nucleotide identity index. Finally, a clinical diagnosis of CRBSI caused by “<em>M. toneyamachuris</em>” was made. Our findings suggest that genomic sequencing is available for the accurate identification of NTM species.</div></div>\",\"PeriodicalId\":11329,\"journal\":{\"name\":\"Diagnostic microbiology and infectious disease\",\"volume\":\"111 3\",\"pages\":\"Article 116626\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-11-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic microbiology and infectious disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0732889324004504\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic microbiology and infectious disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0732889324004504","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Catheter-related bloodstream infection by a newly proposed “Mycobacterium toneyamachuris” in a boy with B-cell precursor acute lymphoblastic leukemia
This report describes a 6-year-old boy who developed non-tuberculosis mycobacteria (NTM) catheter-related bloodstream infection (CRBSI) during treatment for B-cell precursor acute lymphoblastic leukemia. A Hickman catheter was inserted before starting treatment. He developed a fever during chemotherapy, and blood culture was drawn from the catheter. Blurred Gram-positive bacilli were found in Gram stain, looked positive in Ziehl–Neelsen stain, and were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry as Mycobacterium mucogenicum phocaicum group. The administration of clarithromycin and amikacin was started and the Hickman catheter was removed. We performed genomic sequencing to obtain accurate identification, demonstrating that this microorganism was identified as “M. toneyamachuris” calculated by the average nucleotide identity index. Finally, a clinical diagnosis of CRBSI caused by “M. toneyamachuris” was made. Our findings suggest that genomic sequencing is available for the accurate identification of NTM species.
期刊介绍:
Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.