纳米多孔微颗粒的纤维素纳米原纤维：流化床常压喷雾冷冻干燥的效果

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL

Powder Technology Pub Date : 2024-11-27 DOI:10.1016/j.powtec.2024.120502

J.M. Silva , C.C.C. Teixeira , L.A. Tacon , L.V.D. Freitas , A.B. Meneguin , H.S. Barud , L.A.P. Freitas

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引用次数: 0

摘要

纤维素纳米纤维是一种资源丰富、成本低、可生物降解和无毒的材料，是医药领域产品的技术替代品。本研究旨在探讨流化床常压喷雾冷冻干燥对纤维素纳米纤维特性的影响，并与常规喷雾和冷冻干燥方法进行比较。经大气喷雾冷冻干燥的纳米纤维含水率为2.3%，平均粒径为4.0 μm，圆度为0.86，休止角为27.3°。此外，大气喷雾冷冻干燥的纤维素纳米纤维与其他样品的固体状态评价显示出非常相似的化学和热特性，但相对结晶度为45.3%，与喷雾干燥粉末相似。此外，大气喷雾冷冻干燥的纤维素纳米纤维最重要的特征是它们的形态，因为与其他方法不同，它们会产生高度的纳米孔结构。纤维素纳米纤维的常压-喷雾-冷冻干燥可能成为制备药用微海绵的一种新的有吸引力的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nanoporous microparticles of cellulose nanofibrils: The effect of fluid bed atmospheric spray freeze drying

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Nanoporous microparticles of cellulose nanofibrils: The effect of fluid bed atmospheric spray freeze drying

Cellulose nanofibers are abundant, low-cost, biodegradable and non-toxic materials that are a technological alternative for products in pharmaceutical field. The aim of this study was to investigate the effect of fluid bed atmospheric spray freeze drying on cellulose nanofibers characteristics, and compare to conventional spray and freeze drying methods. The atmospheric spray freeze dried nanofibers had moisture content of 2.3 %, mean size 4.0 μm, circularity of 0.86 and angle of repose of 27.3°. Also, solid state evaluation of atmospheric spray freeze dried cellulose nanofibers and other samples showed very similar chemical and thermal characteristics, but a relative crystallinity of 45.3 %, similar to spray dried powders. Furthermore, the most important feature of atmospheric-spray-freeze-dried cellulose nanofibers is their morphology, since unlike the other methods those resulted in highly nanoporous structures. The atmospheric-spray-freeze-drying of cellulose nanofibers may become a new and attractive alternative for the preparation of microsponges for pharmaceutical applications.

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.